Desmoplastic small round cell tumor of the lung

Salahuddin Syed, Abida K. Haque, Hal K. Hawkins, Poul H B Sorensen, Daniel F. Cowan

Research output: Contribution to journalArticle

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Abstract

An extra-abdominal desmoplastic small round cell tumor (DSRCT) of the lung with immunohistochemical, ultrastructural, and cytogenetic evidence of multidirectional differentiation is reported. We demonstrate that DSRCTs of the lung and pleura show morphologic, molecular, genetic, and ultrastructural features similar to DSRCTs arising in other sites. The tumor showed coexpression of cytokeratins (AE1/3, epithelial membrane antigen, CAM 5.2) and mesenchymal markers (vimentin, desmin, neuron-specific enolase), as well as WT1. Ultrastructurally, intracytoplasmic whorls of intermediate filaments, similar to previous descriptions of DSRCT in nonthoracic sites, were also demonstrated in this case. EWS-WT1 gene fusion characteristic of DSRCT with the t(11;22)(q13;q12) translocation was demonstrated in this tumor.

Original languageEnglish (US)
Pages (from-to)1226-1228
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume126
Issue number10
StatePublished - Oct 2002

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Desmoplastic Small Round Cell Tumor
Lung
Keratin-3
Mucin-1
Desmin
Intermediate Filaments
Phosphopyruvate Hydratase
Pleura
Gene Fusion
Vimentin
Cytogenetics
Molecular Biology
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Syed, S., Haque, A. K., Hawkins, H. K., Sorensen, P. H. B., & Cowan, D. F. (2002). Desmoplastic small round cell tumor of the lung. Archives of Pathology and Laboratory Medicine, 126(10), 1226-1228.

Desmoplastic small round cell tumor of the lung. / Syed, Salahuddin; Haque, Abida K.; Hawkins, Hal K.; Sorensen, Poul H B; Cowan, Daniel F.

In: Archives of Pathology and Laboratory Medicine, Vol. 126, No. 10, 10.2002, p. 1226-1228.

Research output: Contribution to journalArticle

Syed, S, Haque, AK, Hawkins, HK, Sorensen, PHB & Cowan, DF 2002, 'Desmoplastic small round cell tumor of the lung', Archives of Pathology and Laboratory Medicine, vol. 126, no. 10, pp. 1226-1228.
Syed S, Haque AK, Hawkins HK, Sorensen PHB, Cowan DF. Desmoplastic small round cell tumor of the lung. Archives of Pathology and Laboratory Medicine. 2002 Oct;126(10):1226-1228.
Syed, Salahuddin ; Haque, Abida K. ; Hawkins, Hal K. ; Sorensen, Poul H B ; Cowan, Daniel F. / Desmoplastic small round cell tumor of the lung. In: Archives of Pathology and Laboratory Medicine. 2002 ; Vol. 126, No. 10. pp. 1226-1228.
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