Detection of human papillomavirus in primary hepatocellular carcinoma

F. Scinicariello, T. Sato, C. S. Lee, H. C. Hsu, T. S. Chan, S. K. Tyring

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Human papillomaviruses (HPV) have been linked causally to some human cancers such as cervical carcinoma. To determine whether any additional type of human malignancy contained HPV DNA we examined 16 hepatocellulur carcinoma (HCC) specimens by Southern blot technique and by polymerase chain reaction (PCR). One HCC contained HPV 16 DNA as demonstrated by both Southern blot and PCR. Two other HCC samples contained HPV 18-related nucleotide sequences by PCR but were negative by Southern blot of genomic DNA. HPV could have been carried via blood to the liver thus indirectly supporting the presence of an HPV viremia. Our findings suggest that oncogenic HPV might constitute a cofactor acting synergistically with hepatitis B virus (HBV) in the development of the HCC in these patients. Alternatively the presence of HPV in the tumor tissue might be the result of an opportunistic infection.

Original languageEnglish (US)
Pages (from-to)763-766
Number of pages4
JournalAnticancer Research
Volume12
Issue number3
StatePublished - 1992

Fingerprint

Hepatocellular Carcinoma
Carcinoma
Southern Blotting
Polymerase Chain Reaction
DNA
Human papillomavirus 18
Neoplasms
Human papillomavirus 16
Viremia
Opportunistic Infections
Hepatitis B virus
Liver

Keywords

  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Human papillomavirus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Scinicariello, F., Sato, T., Lee, C. S., Hsu, H. C., Chan, T. S., & Tyring, S. K. (1992). Detection of human papillomavirus in primary hepatocellular carcinoma. Anticancer Research, 12(3), 763-766.

Detection of human papillomavirus in primary hepatocellular carcinoma. / Scinicariello, F.; Sato, T.; Lee, C. S.; Hsu, H. C.; Chan, T. S.; Tyring, S. K.

In: Anticancer Research, Vol. 12, No. 3, 1992, p. 763-766.

Research output: Contribution to journalArticle

Scinicariello, F, Sato, T, Lee, CS, Hsu, HC, Chan, TS & Tyring, SK 1992, 'Detection of human papillomavirus in primary hepatocellular carcinoma', Anticancer Research, vol. 12, no. 3, pp. 763-766.
Scinicariello F, Sato T, Lee CS, Hsu HC, Chan TS, Tyring SK. Detection of human papillomavirus in primary hepatocellular carcinoma. Anticancer Research. 1992;12(3):763-766.
Scinicariello, F. ; Sato, T. ; Lee, C. S. ; Hsu, H. C. ; Chan, T. S. ; Tyring, S. K. / Detection of human papillomavirus in primary hepatocellular carcinoma. In: Anticancer Research. 1992 ; Vol. 12, No. 3. pp. 763-766.
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