Detection of prostate cancer with optoacoustic tomography: Feasibility and modeling

Valeri G. Andreev, Anatoly E. Ponomaryov, P. Mark Henrichs, Massoud Motamedi, Eduardo Orihuela, Eduardo Eyzaguirre, Alexander A. Oraevsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Scopus citations

Abstract

A laser optoacoustic imaging system (LOIS) with a transrectal probe might become useful for detection of prostate cancer, for guidance of prostate biopsies, and for monitoring of therapy for prostate cancer. Two main components of a prostate optoacoustic imaging system were examined in the feasibility study reported here. (1) The optical contrast between cancerous tissues and normal or benign tissues in the prostate in a surgically removed prostate specimen was tested with a LOIS originally designed for breast imaging. These pilot imaging studies demonstrated that there is sufficient optoacoustic tissue contrast for tumor detection in a prostate with an advanced carcinoma. (2) A computer model of a miniature array of optoacoustic transducers sensitive to an ultrawide band of ultrasonic frequencies was developed and used for evaluation of detector arrays of various different configurations and dimensions. We considered the importance of the number of transducer elements in the array, the thickness of the piezoelectric polymer film, poly(vinylidene fluoride) in each transducer, and the overall geometry of the array. Imaging with an axial resolution of better than 200 μm will be possible. The lateral resolution will be 0.5 mm to 1 mm, depending on the field of view. These results are being used in the construction of a working probe for optoacoustic imaging of the prostate.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.A. Oraevsky
Pages45-57
Number of pages13
Volume4960
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Biomedical Optoacoutics IV - San Jose, CA, United States
Duration: Jan 26 2003Jan 27 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Biomedical Optoacoutics IV
CountryUnited States
CitySan Jose, CA
Period1/26/031/27/03

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Keywords

  • Optoacoustic imaging
  • Prostate cancer
  • Transducers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Andreev, V. G., Ponomaryov, A. E., Henrichs, P. M., Motamedi, M., Orihuela, E., Eyzaguirre, E., & Oraevsky, A. A. (2003). Detection of prostate cancer with optoacoustic tomography: Feasibility and modeling. In A. A. Oraevsky (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4960, pp. 45-57) https://doi.org/10.1117/12.483489