Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon

Lucy M. Ndip, Eric B. Fokam, Donald Bouyer, Roland N. Ndip, Vincent P K Titanji, David Walker, Jere McBride

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Rickettsia africae was identified in seven (6%) of 118 patients with acute fevers of unknown etiology proven not to be malaria or typhoid fever from clinics along the coastal region of Cameroon by polymerase chain reaction (PCR) amplification and sequencing of the citrate synthase (gltA) and outer membrane protein A (ompA) genes of Rickettsia. The majority (71%) of the patients were female. Clinical manifestations included fever (100%), headache (71%), myalgia (71%), arthralgia (43%), pulmonary involvement (29%), and diffuse rash (14%). Moreover, R. africae was detected by PCR amplification and sequence analysis of the gltA and ompA genes in 62 (75%) of 83 adult Amblyomma variegatum ticks collected from cattle in the same region. These results confirm the presence of a previously unrecognized infectious disease in the indigenous Cameroonian population, as well as extend the established range of R. africae.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume71
Issue number3
StatePublished - Sep 2004

Fingerprint

vif Genes
Rickettsia
Cameroon
Ticks
Membrane Proteins
Fever
Citrate (si)-Synthase
Polymerase Chain Reaction
Typhoid Fever
Myalgia
Arthralgia
Exanthema
Population Groups
Malaria
Communicable Diseases
Sequence Analysis
Headache
Lung

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon. / Ndip, Lucy M.; Fokam, Eric B.; Bouyer, Donald; Ndip, Roland N.; Titanji, Vincent P K; Walker, David; McBride, Jere.

In: American Journal of Tropical Medicine and Hygiene, Vol. 71, No. 3, 09.2004, p. 363-366.

Research output: Contribution to journalArticle

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