Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination

E. Lavi; E. M. Murray; S. Makino; S. A. Stohlman; M. M.C. Lai; S. R. Weiss

Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination

E. Lavi, E. M. Murray, S. Makino, S. A. Stohlman, M. M.C. Lai, S. R. Weiss

Research output: Contribution to journal › Article › peer-review

Abstract

Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.

Original language	English (US)
Pages (from-to)	570-578
Number of pages	9
Journal	Laboratory Investigation
Volume	62
Issue number	5
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Cite this

@article{ed4e2c8a090148b4a23cc7f80d3a2e97,

title = "Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination",

abstract = "Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.",

author = "E. Lavi and Murray, {E. M.} and S. Makino and Stohlman, {S. A.} and Lai, {M. M.C.} and Weiss, {S. R.}",

year = "1990",

language = "English (US)",

volume = "62",

pages = "570--578",

journal = "Laboratory Investigation",

issn = "0023-6837",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination

AU - Lavi, E.

AU - Murray, E. M.

AU - Makino, S.

AU - Stohlman, S. A.

AU - Lai, M. M.C.

AU - Weiss, S. R.

PY - 1990

Y1 - 1990

N2 - Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.

AB - Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.

UR - http://www.scopus.com/inward/record.url?scp=0025285840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025285840&partnerID=8YFLogxK

M3 - Article

C2 - 2160561

AN - SCOPUS:0025285840

SN - 0023-6837

VL - 62

SP - 570

EP - 578

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 5

ER -

Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this