Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion

T. Isago, L. D. Traber, David Herndon, S. Abdi, K. Fujioka, D. L. Traber

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We devised a technique that permitted elevation of pulmonary pressures in unanesthetized sheep by occluding their pulmonary veins. Using this technique, we raised pulmonary capillary pressure from a baseline of 13.2 ± 2.2 to 35.3 ± 5.1 mmHg. This increased lung lymph flow (from 8.8 ± 2.7 to 53.1 ± 13.9 ml/h). We estimated the pulmonary microvascular oncotic reflection coefficient and found it to be 0.82 ± 0.05 (SD). The filtration coefficient was 0.019 ± 0.005 ml·mmHg-1·min-1. During the period of increased pressure, the animals had stable arterial pressures and cardiac outputs. None of the animals developed blood coagulation problems. These data illustrate the usefulness of pulmonary venous occlusion to elevate pulmonary microvascular pressure to obtain plasma-to-lymph protein concentration ratios independent of flow, allowing for the calculation of the oncotic reflection coefficient.

Original languageEnglish (US)
Pages (from-to)2311-2316
Number of pages6
JournalJournal of Applied Physiology
Volume69
Issue number6
StatePublished - 1990

Fingerprint

Sheep
Lung
Pressure
Lymph
Pulmonary Veins
Blood Coagulation
Cardiac Output
Arterial Pressure
Proteins

Keywords

  • lymph-to-plasma protein concentration
  • pulmonary lymph flow
  • pulmonary venous occluders

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Isago, T., Traber, L. D., Herndon, D., Abdi, S., Fujioka, K., & Traber, D. L. (1990). Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion. Journal of Applied Physiology, 69(6), 2311-2316.

Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion. / Isago, T.; Traber, L. D.; Herndon, David; Abdi, S.; Fujioka, K.; Traber, D. L.

In: Journal of Applied Physiology, Vol. 69, No. 6, 1990, p. 2311-2316.

Research output: Contribution to journalArticle

Isago, T, Traber, LD, Herndon, D, Abdi, S, Fujioka, K & Traber, DL 1990, 'Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion', Journal of Applied Physiology, vol. 69, no. 6, pp. 2311-2316.
Isago T, Traber LD, Herndon D, Abdi S, Fujioka K, Traber DL. Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion. Journal of Applied Physiology. 1990;69(6):2311-2316.
Isago, T. ; Traber, L. D. ; Herndon, David ; Abdi, S. ; Fujioka, K. ; Traber, D. L. / Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 6. pp. 2311-2316.
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