Determination of the protein composition of the occlusion-derived virus of Autographa californica nucleopolyhedrovirus

S. C. Braunagel, W. K. Russell, G. Rosas-Acosta, D. H. Russell, M. D. Summers

Research output: Contribution to journalArticle

154 Scopus citations


The occlusion derived form of baculovirus is specially adapted for primary infection of the host midgut epithelium. As such, the virion must contain the proteins essential for host range determination and initiation of infection. Because knowledge of virion composition is a prerequisite for functional investigation, this study used a combination of techniques to identify the proteins present within or associated with the occlusion-derived virus (ODV) virion. Thirty-one proteins, including proteins known to be essential for viral DNA replication, were identified with confidence. An additional 13 proteins were identified by using one of the three techniques. A comparison of gene conservation among the ODV proteins encoded in the 16 sequenced baculoviridae genomes is presented. With knowledge of the composition of ODV, it is now possible to target proteins and study their role(s) during primary infection.

Original languageEnglish (US)
Pages (from-to)9797-9802
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number17
StatePublished - Aug 19 2003
Externally publishedYes


ASJC Scopus subject areas

  • General

Cite this