Deterministic modeling of interferon-beta signaling pathway

Jaroslaw Smieja, Mohammad Jamaluddin, Allan Brasier, Marek Kimmel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The paper is concerned with dynamical modeling of early and late gene expression in one of Interferon-β induced signaling pathways. First, the biological background is given. Subsequently, the importance of stochastic nature of biological processes is addressed. Then, the assumptions underlying their deterministic modeling are presented and the mathematical model is introduced. Finally, the methodology for identification of model parameters is briefly described, followed by the presentation of experimental and simulation results. In addition to analysis of the particular regulatory network, this work also builds a framework for modeling of other signalling pathways whose not all components are known.

Original languageEnglish (US)
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages423-428
Number of pages6
Volume6
EditionPART 1
StatePublished - 2006
Event6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 - Reims, France
Duration: Aug 20 2006Aug 22 2006

Other

Other6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
CountryFrance
CityReims
Period8/20/068/22/06

Fingerprint

Interferons
Gene expression
Identification (control systems)
Mathematical models

Keywords

  • Biocybernetics
  • Biomedical systems
  • Dynamic modelling
  • Feedback systems

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Smieja, J., Jamaluddin, M., Brasier, A., & Kimmel, M. (2006). Deterministic modeling of interferon-beta signaling pathway. In IFAC Proceedings Volumes (IFAC-PapersOnline) (PART 1 ed., Vol. 6, pp. 423-428)

Deterministic modeling of interferon-beta signaling pathway. / Smieja, Jaroslaw; Jamaluddin, Mohammad; Brasier, Allan; Kimmel, Marek.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 6 PART 1. ed. 2006. p. 423-428.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Smieja, J, Jamaluddin, M, Brasier, A & Kimmel, M 2006, Deterministic modeling of interferon-beta signaling pathway. in IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 edn, vol. 6, pp. 423-428, 6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006, Reims, France, 8/20/06.
Smieja J, Jamaluddin M, Brasier A, Kimmel M. Deterministic modeling of interferon-beta signaling pathway. In IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 ed. Vol. 6. 2006. p. 423-428
Smieja, Jaroslaw ; Jamaluddin, Mohammad ; Brasier, Allan ; Kimmel, Marek. / Deterministic modeling of interferon-beta signaling pathway. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 6 PART 1. ed. 2006. pp. 423-428
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