Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel

Maurine D. Miner, Mark Hatherill, Vidya Mave, Glenda E. Gray, Sharon Nachman, Sarah W. Read, Richard G. White, Anneke Hesseling, Frank Cobelens, Sheral Patel, Mike Frick, Theodore Bailey, Robert Seder, Joanne Flynn, Jyothi Rengarajan, Deepak Kaushal, Willem Hanekom, Alexander C. Schmidt, Thomas J. Scriba, Elisa NemesErica Andersen-Nissen, Alan Landay, Susan E. Dorman, Grace Aldrovandi, Lisa M. Cranmer, Cheryl L. Day, Alberto L. Garcia-Basteiro, Andrew Fiore-Gartland, Robin Mogg, James G. Kublin, Amita Gupta, Gavin Churchyard

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

New tuberculosis vaccine candidates that are in the development pipeline need to be studied in people with HIV, who are at high risk of acquiring Mycobacterium tuberculosis infection and tuberculosis disease and tend to develop less robust vaccine-induced immune responses. To address the gaps in developing tuberculosis vaccines for people with HIV, a series of symposia was held that posed six framing questions to a panel of international experts: What is the use case or rationale for developing tuberculosis vaccines? What is the landscape of tuberculosis vaccines? Which vaccine candidates should be prioritised? What are the tuberculosis vaccine trial design considerations? What is the role of immunological correlates of protection? What are the gaps in preclinical models for studying tuberculosis vaccines? The international expert panel formulated consensus statements to each of the framing questions, with the intention of informing tuberculosis vaccine development and the prioritisation of clinical trials for inclusion of people with HIV.

Original languageEnglish (US)
Pages (from-to)e791-e800
JournalThe Lancet HIV
Volume9
Issue number11
DOIs
StatePublished - Nov 2022
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Immunology
  • Infectious Diseases
  • Virology

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