Development & validation of LC–MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

Keyphrases

• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 100%
• Pharmacokinetics 100%
• 1-Methyl 100%
• Rat Plasma 100%
• Development Validation 100%
• Quinolinium 100%
• Oral Bioavailability Study 100%
• Plasma Applications 100%
• 5-Amino-1 100%
• Plasma Samples 50%
• Urine Samples 33%
• Rat Urine 33%
• Nicotinamide N-methyltransferase 33%
• Concentration Level 25%
• Oral Administration 16%
• MS Method 16%
• Diabetes 8%
• Obesity 8%
• Chronic Disease 8%
• Mass Spectrometer 8%
• Drug Development 8%
• Xenobiotics 8%
• Oral Bioavailability 8%
• Skeletal muscle 8%
• Clinically Significant 8%
• Pharmacokinetic Study 8%
• Multiple Reaction Monitoring 8%
• Endogenous Substrates 8%
• Adipose Tissue 8%
• Cellular Metabolism 8%
• Excel 8%
• QTRAP 8%
• Oral Dose 8%
• Plasma Concentration 8%
• Intravenous Dose 8%
• Chromatographic Separation 8%
• Acetonitrile 8%
• N-methylation 8%
• Plasma Exposure 8%
• Area under the Curve 8%
• Pathophysiological Conditions 8%
• Solvent System 8%
• Protein Precipitation 8%
• IV Administration 8%
• Nicotinamide 8%
• Mobile Phase 8%
• C18 Column 8%
• Extraction Recovery 8%
• Mean Area 8%
• Oral Route 8%
• Positive Mode 8%
• Matrix Effect 8%
• Storage Conditions 8%
• Acceptable Range 8%
• Elimination Half-life 8%
• Formic Acid 8%
• Preparation Conditions 8%
• Methyltransferase Inhibitor 8%
• Handling Conditions 8%
• Quadruple Mass 8%
• Recovery Effect 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Bioavailability 100%
• Nicotinamide 100%
• Pharmacokinetics 100%
• Methyltransferase 60%
• Chronic Disease 20%
• Xenobiotic Agent 20%
• Drug Development 20%
• Elimination 20%
• Methyltransferase Inhibitor 20%
• Acetonitrile 20%
• Formate 20%