Development and analysis of a small animal model simulating the human postburn hypermetabolic response

David N. Herndon, Douglas W. Wilmore, Arthur D. Mason

Research output: Contribution to journalArticle

152 Scopus citations


Growing guinea pigs and mature rats are good models of the human metabolic response to thermal injury demonstrating a dose-response relationship between burn size and metabolic rate, an elevation in metabolic rate related to the stage of convalescence and hypermetabolism that may be altered but not abated by external heating. A 50% total body surface burn must be produced before reliable elevations in metabolic rate are observed. The mature rat is the best of the three animal models and is suitable for evaluation of the mediators and modulators of the hypermetabolic response to thermal injury.

Original languageEnglish (US)
Pages (from-to)394-403
Number of pages10
JournalJournal of Surgical Research
Issue number5
StatePublished - Nov 1978


ASJC Scopus subject areas

  • Surgery

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