Development of a device for measuring adherence of skin grafts to the wound surface

C. Dong, E. Mead, R. Skalak, Y. C. Fung, J. C. Debes, R. L. Zapata-Sirvent, C. Andree, G. Greenleaf, M. Cooper, J. F. Hansbrough

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Adherence of a biological graft to the wound surface is the most important factor influencing the ultimate success of graft viability. A machine has been developed to test the adherence of biological graft materials to a substrate such as a wound surface. The peeling mode, which yields reproducible quantitative measurements of adherence, is a standard method for testing adhesives. The device is designed to continuously measure the force required to peel the graft from the substrate at a constant rate. This force is a function of the energy of adhesion per unit area of adhered surface. This device has been used to measure the peeling force of (2×2 cm) skin grafts which are applied to full-thickness wounds on mice. Results of tests on adherence of autografts on mice show that the peeling force increases significantly with time over the first 9 days of healing. Thus, this device is useful in quantitative comparison of various skin grafting techniques and artificial grafts.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalAnnals of Biomedical Engineering
Issue number1
StatePublished - Jan 1993
Externally publishedYes


  • Adherence
  • Skin grafts
  • Tensiometer

ASJC Scopus subject areas

  • Biomedical Engineering


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