Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection

R. J. McNichols, A. Gowda, B. A. Bell, R. M. Johnigan, K. H. Calhoun, Massoud Motamedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Oral squamous cell carcinoma is a disease which progresses through a number of well-defined morphological and biochemical changes. Optical coherence tomography (OCT) is a rapidly-evolving, non-invasive imaging modality which allows detailed probing of subsurface tissue structures with resolution on the order of microns. While this technique offers tremendous potential as a diagnostic tool for detection and characterization of oral cancer, OCT imaging is presently associated with a field of view (FOV) on the order of millimeters, and acquisition time on the order of seconds. Thus, OCT's utility as a rapid cancer screening technique is presently limited. On the other hand, imaging of tissue autofluorescence provides a very rapid, high-throughput method for cancer screening. However, while autofluorescence measures may be sensitive to cancer, they are often non-specific and lead to a large number of false positives. In the present work, we have developed a fluorescence image guided optical coherence tomographic (FIG-OCT) probe in which tissue autofluorescence images are simultaneously used to guide OCT image acquisition of suspicious regions in real time. We have begun preclinical pilot studies with this instrument in a DMBA-induced model of oral cancer in the hamster cheek pouch. Initial results indicate that the FIG-OCT approach shows promise as a rapid and effective tool for screening of oral cancer.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT. Vo-Dinh, W.S. Grundfest, D.A. Benaron
Pages23-30
Number of pages8
Volume4254
DOIs
StatePublished - 2001
Externally publishedYes
EventBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III - San Jose, CA, United States
Duration: Jan 21 2001Jan 22 2001

Other

OtherBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III
CountryUnited States
CitySan Jose, CA
Period1/21/011/22/01

Fingerprint

Optical tomography
Screening
tomography
cancer
Fluorescence
Tissue
Imaging techniques
fluorescence
probes
Image acquisition
screening
Throughput
acquisition
hamsters
field of view

Keywords

  • Autofluorescence
  • Cancer detection
  • Fluorescence Imaging
  • Optical coherence Tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

McNichols, R. J., Gowda, A., Bell, B. A., Johnigan, R. M., Calhoun, K. H., & Motamedi, M. (2001). Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection. In T. Vo-Dinh, W. S. Grundfest, & D. A. Benaron (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4254, pp. 23-30) https://doi.org/10.1117/12.427941

Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection. / McNichols, R. J.; Gowda, A.; Bell, B. A.; Johnigan, R. M.; Calhoun, K. H.; Motamedi, Massoud.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T. Vo-Dinh; W.S. Grundfest; D.A. Benaron. Vol. 4254 2001. p. 23-30.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

McNichols, RJ, Gowda, A, Bell, BA, Johnigan, RM, Calhoun, KH & Motamedi, M 2001, Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection. in T Vo-Dinh, WS Grundfest & DA Benaron (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4254, pp. 23-30, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.427941
McNichols RJ, Gowda A, Bell BA, Johnigan RM, Calhoun KH, Motamedi M. Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection. In Vo-Dinh T, Grundfest WS, Benaron DA, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4254. 2001. p. 23-30 https://doi.org/10.1117/12.427941
McNichols, R. J. ; Gowda, A. ; Bell, B. A. ; Johnigan, R. M. ; Calhoun, K. H. ; Motamedi, Massoud. / Development of an endoscopic fluorescence image guided OCT probe for oral cancer detection. Proceedings of SPIE - The International Society for Optical Engineering. editor / T. Vo-Dinh ; W.S. Grundfest ; D.A. Benaron. Vol. 4254 2001. pp. 23-30
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