Development of an experimental hairless guinea pig model for testing ethyl alcohol-associated phototoxicity

Jennifer A. Ray; Maribel I. Colome; Richard F. Wagner

Development of an experimental hairless guinea pig model for testing ethyl alcohol-associated phototoxicity

Jennifer A. Ray, Maribel I. Colome, Richard F. Wagner

Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

In theory, excess ingestion of ethyl alcohol may alter normal porphyrin metabolism through liver damage. A hairless guinea pig model was used to test this hypothesis. Although the initial experimental results were inconclusive, this novel animal model may prove useful for future research about the possible role of ethyl alcohol in phototoxicity and sunburn.

Original language	English (US)
Pages (from-to)	25-37
Number of pages	13
Journal	Skin Cancer
Volume	23
Issue number	1
State	Published - Jan 2008

Keywords

Ethyl alcohol
Guinea pig
Phototoxicity
Porphyrins
Solar simulator
Sunburn

ASJC Scopus subject areas

Oncology
Dermatology

Cite this

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abstract = "In theory, excess ingestion of ethyl alcohol may alter normal porphyrin metabolism through liver damage. A hairless guinea pig model was used to test this hypothesis. Although the initial experimental results were inconclusive, this novel animal model may prove useful for future research about the possible role of ethyl alcohol in phototoxicity and sunburn.",

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N2 - In theory, excess ingestion of ethyl alcohol may alter normal porphyrin metabolism through liver damage. A hairless guinea pig model was used to test this hypothesis. Although the initial experimental results were inconclusive, this novel animal model may prove useful for future research about the possible role of ethyl alcohol in phototoxicity and sunburn.

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KW - Guinea pig

KW - Phototoxicity

KW - Porphyrins

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KW - Sunburn

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Development of an experimental hairless guinea pig model for testing ethyl alcohol-associated phototoxicity

Abstract

Keywords

ASJC Scopus subject areas

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