Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

Eduardo Orihuela; Stephen K. Tyring; Mariela Pow-Sang; Susan Dozier; Richard Cirelli; Istvan Arany; Peter Rady; Ramon Sanchez

doi:10.1016/S0022-5347(01)67363-4

Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

Eduardo Orihuela, Stephen K. Tyring, Mariela Pow-Sang, Susan Dozier, Richard Cirelli, Istvan Arany, Peter Rady, Ramon Sanchez

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Abstract

In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

Original language	English (US)
Pages (from-to)	1940-1943
Number of pages	4
Journal	The Journal of urology
Volume	153
Issue number	6
DOIs	https://doi.org/10.1016/S0022-5347(01)67363-4
State	Published - Jun 1995

ASJC Scopus subject areas

Urology

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title = "Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin",

abstract = "In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.",

author = "Eduardo Orihuela and Tyring, {Stephen K.} and Mariela Pow-Sang and Susan Dozier and Richard Cirelli and Istvan Arany and Peter Rady and Ramon Sanchez",

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AU - Orihuela, Eduardo

AU - Tyring, Stephen K.

AU - Pow-Sang, Mariela

AU - Dozier, Susan

AU - Cirelli, Richard

AU - Arany, Istvan

AU - Rady, Peter

AU - Sanchez, Ramon

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N2 - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

AB - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

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Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

Abstract

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