Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

Eduardo Orihuela, Stephen K. Tyring, Mariela Pow-Sang, Susan Dozier, Richard Cirelli, Istvan Arany, Peter Rady, Ramon Sanchez

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

Original languageEnglish (US)
Pages (from-to)1940-1943
Number of pages4
JournalThe Journal of Urology
Volume153
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Darier Disease
Isotretinoin
Scrotum
Human papillomavirus 16
Squamous Cell Carcinoma
Penis
Retinoids
Environmental Exposure
Carcinogens
Neoplasms
Genome
Carcinoma
Skin
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin. / Orihuela, Eduardo; Tyring, Stephen K.; Pow-Sang, Mariela; Dozier, Susan; Cirelli, Richard; Arany, Istvan; Rady, Peter; Sanchez, Ramon.

In: The Journal of Urology, Vol. 153, No. 6, 1995, p. 1940-1943.

Research output: Contribution to journalArticle

Orihuela, Eduardo ; Tyring, Stephen K. ; Pow-Sang, Mariela ; Dozier, Susan ; Cirelli, Richard ; Arany, Istvan ; Rady, Peter ; Sanchez, Ramon. / Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin. In: The Journal of Urology. 1995 ; Vol. 153, No. 6. pp. 1940-1943.
@article{b32c469357124131b3575a1c91262f82,
title = "Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin",
abstract = "In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.",
author = "Eduardo Orihuela and Tyring, {Stephen K.} and Mariela Pow-Sang and Susan Dozier and Richard Cirelli and Istvan Arany and Peter Rady and Ramon Sanchez",
year = "1995",
doi = "10.1016/S0022-5347(01)67363-4",
language = "English (US)",
volume = "153",
pages = "1940--1943",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

AU - Orihuela, Eduardo

AU - Tyring, Stephen K.

AU - Pow-Sang, Mariela

AU - Dozier, Susan

AU - Cirelli, Richard

AU - Arany, Istvan

AU - Rady, Peter

AU - Sanchez, Ramon

PY - 1995

Y1 - 1995

N2 - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

AB - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

UR - http://www.scopus.com/inward/record.url?scp=0029042459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029042459&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(01)67363-4

DO - 10.1016/S0022-5347(01)67363-4

M3 - Article

C2 - 7752363

AN - SCOPUS:0029042459

VL - 153

SP - 1940

EP - 1943

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -