TY - JOUR
T1 - Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin
AU - Orihuela, Eduardo
AU - Tyring, Stephen K.
AU - Pow-Sang, Mariela
AU - Dozier, Susan
AU - Cirelli, Richard
AU - Arany, Istvan
AU - Rady, Peter
AU - Sanchez, Ramon
PY - 1995/6
Y1 - 1995/6
N2 - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.
AB - In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.
UR - http://www.scopus.com/inward/record.url?scp=0029042459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029042459&partnerID=8YFLogxK
U2 - 10.1016/S0022-5347(01)67363-4
DO - 10.1016/S0022-5347(01)67363-4
M3 - Article
C2 - 7752363
AN - SCOPUS:0029042459
SN - 0022-5347
VL - 153
SP - 1940
EP - 1943
JO - Investigative Urology
JF - Investigative Urology
IS - 6
ER -