Development of Human Papillomavirus Type 16 Associated Squamous Cell Carcinoma of the Scrotum in a Patient with Darier's Disease Treated with Systemic Isotretinoin

Eduardo Orihuela, Stephen K. Tyring, Mariela Pow-Sang, Susan Dozier, Richard Cirelli, Istvan Arany, Peter Rady, Ramon Sanchez

Research output: Contribution to journalArticle

24 Scopus citations


In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

Original languageEnglish (US)
Pages (from-to)1940-1943
Number of pages4
JournalThe Journal of urology
Issue number6
StatePublished - Jun 1995


ASJC Scopus subject areas

  • Urology

Cite this