Abstract
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | Journal of Molecular Neuroscience |
| Volume | 19 |
| Issue number | 1-2 |
| State | Published - Aug 2002 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- Beta-amyloid
- Indole-3-propionic acid
- Oxidative stress
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry
- Genetics
Cite this
Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease. / Bendheim, P. E.; Poeggeler, B.; Neria, E.; Ziv, V.; Pappolla, Miguel; Chain, D. G.
In: Journal of Molecular Neuroscience, Vol. 19, No. 1-2, 08.2002, p. 213-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease
AU - Bendheim, P. E.
AU - Poeggeler, B.
AU - Neria, E.
AU - Ziv, V.
AU - Pappolla, Miguel
AU - Chain, D. G.
PY - 2002/8
Y1 - 2002/8
N2 - The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.
AB - The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.
KW - Alzheimer's disease
KW - Beta-amyloid
KW - Indole-3-propionic acid
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0036675722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036675722&partnerID=8YFLogxK
M3 - Article
C2 - 12212784
AN - SCOPUS:0036675722
VL - 19
SP - 213
EP - 217
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
SN - 0895-8696
IS - 1-2
ER -