Development of serum hexosaminidase activity in infants

Karen Shattuck, Carol Richardson, D. K. Rassin, T. E. Lobe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Serum activity of hexosaminidases A and B has been measured to identify patients with Tay-Sachs and Sandhoff diseases, and may also be influenced by other clinical conditions including neonatal necrotizing enterocolitis. We have characterized the normal developmental pattern of hexosaminidase activity in serum by measuring this enzyme activity in 61 neonates of 27-40 weeks gestation who were followed from birth to age 4-8 weeks. Total serum hexosaminidase activity significantly increased with postnatal and gestational age, and with initiation of enteral feeding. We conclude that serum hexosaminidase activity in infants with clinical conditions that may influence serum activity of this enzyme must be compared to that in normal infants of similar gestational and postnatal ages.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalBiology of the Neonate
Volume49
Issue number3
StatePublished - 1986

Fingerprint

Hexosaminidases
Serum
Gestational Age
Hexosaminidase B
Sandhoff Disease
Hexosaminidase A
Tay-Sachs Disease
Necrotizing Enterocolitis
Enteral Nutrition
Enzymes
Parturition
Newborn Infant
Pregnancy

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Development of serum hexosaminidase activity in infants. / Shattuck, Karen; Richardson, Carol; Rassin, D. K.; Lobe, T. E.

In: Biology of the Neonate, Vol. 49, No. 3, 1986, p. 126-131.

Research output: Contribution to journalArticle

Shattuck, Karen ; Richardson, Carol ; Rassin, D. K. ; Lobe, T. E. / Development of serum hexosaminidase activity in infants. In: Biology of the Neonate. 1986 ; Vol. 49, No. 3. pp. 126-131.
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