Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain

M. El Zein, J. L. Areas, J. Knapka, D. DiPette, B. Holland, P. Al-Karadaghi, H. G. Preuss

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Certain rat strains acutely increase blood pressure (BP) when given diets high in NaCl. Prior results showed that ''salt-sensitive'' rat strains, at least the ones studied, also increase BP in response to sugar loading. To examine this relationship further and learn more about the pathogenesis of sucrose-induced BP elevations, we examined the effects of unilateral nephrectomy (uninephrectomy) on sucrose-induced BP changes. The rationale is based upon the findings that renal mass removal sensitizes BP response to salt loading. Over 15 weeks, augmented sugar (sucrose) consumption by Long-Evans (LE) rats did not increase BP markedly compared to rats consuming a diet relatively low in sugar unless uninephrectomy was performed. The differences in BP caused by the high sugar diet in a uninephrectomized rat could not be explained adequately by alterations in catecholamine excretion, plasma renin activity, excesses in blood volume, or the other parameters examined. However, salt-induced hypertension has been attributed to the presence of circulating substances affecting ion transport. Among the dietary groups, there was a significant correlation between the ability of plasma to depress PAH and TEA renal slice uptake and the difference in BP. This is consistent with the presence of a circulating factor affecting cell transport that has its greatest activity in the high sugar-uninephrectomy group of LE rats. We conclude that reducing renal mass potentiates sugar-induced BP elevation similar to salt-induced BP elevation in a normally resistant rat strain, and the rise of BP may be caused by a circulating factor.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalJournal of the American College of Nutrition
Volume10
Issue number1
StatePublished - 1991

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    El Zein, M., Areas, J. L., Knapka, J., DiPette, D., Holland, B., Al-Karadaghi, P., & Preuss, H. G. (1991). Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain. Journal of the American College of Nutrition, 10(1), 24-33.