Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain

M. El Zein, J. L. Areas, J. Knapka, D. DiPette, B. Holland, P. Al-Karadaghi, H. G. Preuss

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Certain rat strains acutely increase blood pressure (BP) when given diets high in NaCl. Prior results showed that ''salt-sensitive'' rat strains, at least the ones studied, also increase BP in response to sugar loading. To examine this relationship further and learn more about the pathogenesis of sucrose-induced BP elevations, we examined the effects of unilateral nephrectomy (uninephrectomy) on sucrose-induced BP changes. The rationale is based upon the findings that renal mass removal sensitizes BP response to salt loading. Over 15 weeks, augmented sugar (sucrose) consumption by Long-Evans (LE) rats did not increase BP markedly compared to rats consuming a diet relatively low in sugar unless uninephrectomy was performed. The differences in BP caused by the high sugar diet in a uninephrectomized rat could not be explained adequately by alterations in catecholamine excretion, plasma renin activity, excesses in blood volume, or the other parameters examined. However, salt-induced hypertension has been attributed to the presence of circulating substances affecting ion transport. Among the dietary groups, there was a significant correlation between the ability of plasma to depress PAH and TEA renal slice uptake and the difference in BP. This is consistent with the presence of a circulating factor affecting cell transport that has its greatest activity in the high sugar-uninephrectomy group of LE rats. We conclude that reducing renal mass potentiates sugar-induced BP elevation similar to salt-induced BP elevation in a normally resistant rat strain, and the rise of BP may be caused by a circulating factor.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalJournal of the American College of Nutrition
Volume10
Issue number1
StatePublished - 1991

Fingerprint

Nephrectomy
blood pressure
Blood Pressure
sugars
rats
Salts
Sucrose
Long Evans Rats
salts
Diet
kidneys
Kidney
sucrose
low sugar diet
Hypertension
renin
Ion Transport
blood volume
Blood Volume
ion transport

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

El Zein, M., Areas, J. L., Knapka, J., DiPette, D., Holland, B., Al-Karadaghi, P., & Preuss, H. G. (1991). Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain. Journal of the American College of Nutrition, 10(1), 24-33.

Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain. / El Zein, M.; Areas, J. L.; Knapka, J.; DiPette, D.; Holland, B.; Al-Karadaghi, P.; Preuss, H. G.

In: Journal of the American College of Nutrition, Vol. 10, No. 1, 1991, p. 24-33.

Research output: Contribution to journalArticle

El Zein, M, Areas, JL, Knapka, J, DiPette, D, Holland, B, Al-Karadaghi, P & Preuss, HG 1991, 'Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain', Journal of the American College of Nutrition, vol. 10, no. 1, pp. 24-33.
El Zein M, Areas JL, Knapka J, DiPette D, Holland B, Al-Karadaghi P et al. Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain. Journal of the American College of Nutrition. 1991;10(1):24-33.
El Zein, M. ; Areas, J. L. ; Knapka, J. ; DiPette, D. ; Holland, B. ; Al-Karadaghi, P. ; Preuss, H. G. / Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain. In: Journal of the American College of Nutrition. 1991 ; Vol. 10, No. 1. pp. 24-33.
@article{235bbb13d6f84d00924c74aab4039374,
title = "Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain",
abstract = "Certain rat strains acutely increase blood pressure (BP) when given diets high in NaCl. Prior results showed that ''salt-sensitive'' rat strains, at least the ones studied, also increase BP in response to sugar loading. To examine this relationship further and learn more about the pathogenesis of sucrose-induced BP elevations, we examined the effects of unilateral nephrectomy (uninephrectomy) on sucrose-induced BP changes. The rationale is based upon the findings that renal mass removal sensitizes BP response to salt loading. Over 15 weeks, augmented sugar (sucrose) consumption by Long-Evans (LE) rats did not increase BP markedly compared to rats consuming a diet relatively low in sugar unless uninephrectomy was performed. The differences in BP caused by the high sugar diet in a uninephrectomized rat could not be explained adequately by alterations in catecholamine excretion, plasma renin activity, excesses in blood volume, or the other parameters examined. However, salt-induced hypertension has been attributed to the presence of circulating substances affecting ion transport. Among the dietary groups, there was a significant correlation between the ability of plasma to depress PAH and TEA renal slice uptake and the difference in BP. This is consistent with the presence of a circulating factor affecting cell transport that has its greatest activity in the high sugar-uninephrectomy group of LE rats. We conclude that reducing renal mass potentiates sugar-induced BP elevation similar to salt-induced BP elevation in a normally resistant rat strain, and the rise of BP may be caused by a circulating factor.",
author = "{El Zein}, M. and Areas, {J. L.} and J. Knapka and D. DiPette and B. Holland and P. Al-Karadaghi and Preuss, {H. G.}",
year = "1991",
language = "English (US)",
volume = "10",
pages = "24--33",
journal = "Journal of the American College of Nutrition",
issn = "0731-5724",
publisher = "American College Of Nutrition",
number = "1",

}

TY - JOUR

T1 - Development of sugar-induced blood pressure elevation after uninephrectomy in a resistant rat strain

AU - El Zein, M.

AU - Areas, J. L.

AU - Knapka, J.

AU - DiPette, D.

AU - Holland, B.

AU - Al-Karadaghi, P.

AU - Preuss, H. G.

PY - 1991

Y1 - 1991

N2 - Certain rat strains acutely increase blood pressure (BP) when given diets high in NaCl. Prior results showed that ''salt-sensitive'' rat strains, at least the ones studied, also increase BP in response to sugar loading. To examine this relationship further and learn more about the pathogenesis of sucrose-induced BP elevations, we examined the effects of unilateral nephrectomy (uninephrectomy) on sucrose-induced BP changes. The rationale is based upon the findings that renal mass removal sensitizes BP response to salt loading. Over 15 weeks, augmented sugar (sucrose) consumption by Long-Evans (LE) rats did not increase BP markedly compared to rats consuming a diet relatively low in sugar unless uninephrectomy was performed. The differences in BP caused by the high sugar diet in a uninephrectomized rat could not be explained adequately by alterations in catecholamine excretion, plasma renin activity, excesses in blood volume, or the other parameters examined. However, salt-induced hypertension has been attributed to the presence of circulating substances affecting ion transport. Among the dietary groups, there was a significant correlation between the ability of plasma to depress PAH and TEA renal slice uptake and the difference in BP. This is consistent with the presence of a circulating factor affecting cell transport that has its greatest activity in the high sugar-uninephrectomy group of LE rats. We conclude that reducing renal mass potentiates sugar-induced BP elevation similar to salt-induced BP elevation in a normally resistant rat strain, and the rise of BP may be caused by a circulating factor.

AB - Certain rat strains acutely increase blood pressure (BP) when given diets high in NaCl. Prior results showed that ''salt-sensitive'' rat strains, at least the ones studied, also increase BP in response to sugar loading. To examine this relationship further and learn more about the pathogenesis of sucrose-induced BP elevations, we examined the effects of unilateral nephrectomy (uninephrectomy) on sucrose-induced BP changes. The rationale is based upon the findings that renal mass removal sensitizes BP response to salt loading. Over 15 weeks, augmented sugar (sucrose) consumption by Long-Evans (LE) rats did not increase BP markedly compared to rats consuming a diet relatively low in sugar unless uninephrectomy was performed. The differences in BP caused by the high sugar diet in a uninephrectomized rat could not be explained adequately by alterations in catecholamine excretion, plasma renin activity, excesses in blood volume, or the other parameters examined. However, salt-induced hypertension has been attributed to the presence of circulating substances affecting ion transport. Among the dietary groups, there was a significant correlation between the ability of plasma to depress PAH and TEA renal slice uptake and the difference in BP. This is consistent with the presence of a circulating factor affecting cell transport that has its greatest activity in the high sugar-uninephrectomy group of LE rats. We conclude that reducing renal mass potentiates sugar-induced BP elevation similar to salt-induced BP elevation in a normally resistant rat strain, and the rise of BP may be caused by a circulating factor.

UR - http://www.scopus.com/inward/record.url?scp=0025876274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025876274&partnerID=8YFLogxK

M3 - Article

C2 - 2010576

AN - SCOPUS:0025876274

VL - 10

SP - 24

EP - 33

JO - Journal of the American College of Nutrition

JF - Journal of the American College of Nutrition

SN - 0731-5724

IS - 1

ER -