Development of treatment strategies to combat Ebola and Marburg viruses

Jason Paragas, Thomas Geisbert

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalExpert Review of Anti-Infective Therapy
Volume4
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Marburgvirus
Ebolavirus
Biological Warfare Agents
Virus Diseases
Critical Pathways
Infection
Primates
Fever
Technology
Health
Therapeutics

Keywords

  • Antiviral
  • Ebola virus
  • Filovirus
  • Marburg virus
  • Therapy
  • Treatment

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Development of treatment strategies to combat Ebola and Marburg viruses. / Paragas, Jason; Geisbert, Thomas.

In: Expert Review of Anti-Infective Therapy, Vol. 4, No. 1, 02.2006, p. 67-76.

Research output: Contribution to journalArticle

@article{8ac4b38a4b9d4ea58a7b6455c40635a8,
title = "Development of treatment strategies to combat Ebola and Marburg viruses",
abstract = "Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.",
keywords = "Antiviral, Ebola virus, Filovirus, Marburg virus, Therapy, Treatment",
author = "Jason Paragas and Thomas Geisbert",
year = "2006",
month = "2",
doi = "10.1586/14787210.4.1.67",
language = "English (US)",
volume = "4",
pages = "67--76",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Expert Reviews Ltd.",
number = "1",

}

TY - JOUR

T1 - Development of treatment strategies to combat Ebola and Marburg viruses

AU - Paragas, Jason

AU - Geisbert, Thomas

PY - 2006/2

Y1 - 2006/2

N2 - Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.

AB - Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.

KW - Antiviral

KW - Ebola virus

KW - Filovirus

KW - Marburg virus

KW - Therapy

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=33645094697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645094697&partnerID=8YFLogxK

U2 - 10.1586/14787210.4.1.67

DO - 10.1586/14787210.4.1.67

M3 - Article

VL - 4

SP - 67

EP - 76

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

SN - 1478-7210

IS - 1

ER -