Development of treatment strategies to combat Ebola and Marburg viruses

Jason Paragas, Thomas W. Geisbert

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalExpert Review of Anti-Infective Therapy
Volume4
Issue number1
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Keywords

  • Antiviral
  • Ebola virus
  • Filovirus
  • Marburg virus
  • Therapy
  • Treatment

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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