Abstract
Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 67-76 |
| Number of pages | 10 |
| Journal | Expert Review of Anti-Infective Therapy |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2006 |
| Externally published | Yes |
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Keywords
- Antiviral
- Ebola virus
- Filovirus
- Marburg virus
- Therapy
- Treatment
ASJC Scopus subject areas
- Infectious Diseases
- Parasitology
Cite this
Development of treatment strategies to combat Ebola and Marburg viruses. / Paragas, Jason; Geisbert, Thomas.
In: Expert Review of Anti-Infective Therapy, Vol. 4, No. 1, 02.2006, p. 67-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of treatment strategies to combat Ebola and Marburg viruses
AU - Paragas, Jason
AU - Geisbert, Thomas
PY - 2006/2
Y1 - 2006/2
N2 - Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.
AB - Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.
KW - Antiviral
KW - Ebola virus
KW - Filovirus
KW - Marburg virus
KW - Therapy
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=33645094697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645094697&partnerID=8YFLogxK
U2 - 10.1586/14787210.4.1.67
DO - 10.1586/14787210.4.1.67
M3 - Article
C2 - 16441210
AN - SCOPUS:33645094697
VL - 4
SP - 67
EP - 76
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 1
ER -