@article{8ac4b38a4b9d4ea58a7b6455c40635a8,
title = "Development of treatment strategies to combat Ebola and Marburg viruses",
abstract = "Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential biological weapons. To date, there are no therapeutic options available for the prophylaxis or treatment of infected individuals. The recognition that Ebola and Marburg viruses may be exploited as biological weapons has resulted in major efforts to develop modalities to counter infection. In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections.",
keywords = "Antiviral, Ebola virus, Filovirus, Marburg virus, Therapy, Treatment",
author = "Jason Paragas and Geisbert, {Thomas W.}",
note = "Funding Information: Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. From their laboratory, the authors thank Denise Braun, Aura Garrison and Joan Geisbert for contributing to the data cited in this review. The authors thank Lisa Hensley for helpful discussions. The authors are also grateful to the contribution of many in the field. Work on filoviruses at US Army Medical Research Institute of Infectious Diseases (USAMRIID) was supported by the Defense Threat Reduction Agency and the Medical Chemical/Biological Defense Research Program, US Army Medical Research and Material Command (project numbers 02–4-4J-081, 03–4-7J-020 and 04–4-7J-012). Research conducted at USAMRIID was performed in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. USAMRIID is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International.",
year = "2006",
month = feb,
doi = "10.1586/14787210.4.1.67",
language = "English (US)",
volume = "4",
pages = "67--76",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Expert Reviews Ltd.",
number = "1",
}