Developmental profile of the hypothalamo-pituitary-adrenal axis response to nerve growth factor

Giulio Taglialatela, J. Regino Perez-Polo

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    The developmental profile of the hypothalamo-pituitary-adrenal axis (HPAA) response to nerve growth factor (NGF) in the rat was determined. NGF induced HPAA activity as assayed by increased serum corticosterone levels in pups that were ≥ 15 days of age. Since the development of an HPAA response to NGF is parallel to synaptogenesis in the hippocampus and to the regulation of HPAA function by the hippocampus, these findings support the hypothesis that serum NGF activates the HPAA by acting within the CNS.

    Original languageEnglish (US)
    Pages (from-to)231-234
    Number of pages4
    JournalNeuroscience Letters
    Volume182
    Issue number2
    DOIs
    StatePublished - Dec 5 1994

    Keywords

    • Corticosterone
    • Development
    • Hippocampus
    • Hypothalamo-pituitary-adrenal axis
    • Nerve growth factor
    • Stress

    ASJC Scopus subject areas

    • Neuroscience(all)

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