Developmental profile of the hypothalamo-pituitary-adrenal axis response to nerve growth factor

Giulio Taglialatela; J. Regino Perez-Polo

doi:10.1016/0304-3940(94)90804-4

Developmental profile of the hypothalamo-pituitary-adrenal axis response to nerve growth factor

Giulio Taglialatela, J. Regino Perez-Polo

Neurology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The developmental profile of the hypothalamo-pituitary-adrenal axis (HPAA) response to nerve growth factor (NGF) in the rat was determined. NGF induced HPAA activity as assayed by increased serum corticosterone levels in pups that were ≥ 15 days of age. Since the development of an HPAA response to NGF is parallel to synaptogenesis in the hippocampus and to the regulation of HPAA function by the hippocampus, these findings support the hypothesis that serum NGF activates the HPAA by acting within the CNS.

Original language	English (US)
Pages (from-to)	231-234
Number of pages	4
Journal	Neuroscience Letters
Volume	182
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90804-4
State	Published - Dec 5 1994

Keywords

Corticosterone
Development
Hippocampus
Hypothalamo-pituitary-adrenal axis
Nerve growth factor
Stress

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90804-4

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title = "Developmental profile of the hypothalamo-pituitary-adrenal axis response to nerve growth factor",

abstract = "The developmental profile of the hypothalamo-pituitary-adrenal axis (HPAA) response to nerve growth factor (NGF) in the rat was determined. NGF induced HPAA activity as assayed by increased serum corticosterone levels in pups that were ≥ 15 days of age. Since the development of an HPAA response to NGF is parallel to synaptogenesis in the hippocampus and to the regulation of HPAA function by the hippocampus, these findings support the hypothesis that serum NGF activates the HPAA by acting within the CNS.",

keywords = "Corticosterone, Development, Hippocampus, Hypothalamo-pituitary-adrenal axis, Nerve growth factor, Stress",

author = "Giulio Taglialatela and Perez-Polo, {J. Regino}",

note = "Funding Information: Supported in part by a Seed Money Research Grant from the Center on Aging of the University of Texas Medical Branch. This is Publication 23 supported by USPHS Grant PO1 AG10514 awarded by the National Institute on Aging.",

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AU - Perez-Polo, J. Regino

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AB - The developmental profile of the hypothalamo-pituitary-adrenal axis (HPAA) response to nerve growth factor (NGF) in the rat was determined. NGF induced HPAA activity as assayed by increased serum corticosterone levels in pups that were ≥ 15 days of age. Since the development of an HPAA response to NGF is parallel to synaptogenesis in the hippocampus and to the regulation of HPAA function by the hippocampus, these findings support the hypothesis that serum NGF activates the HPAA by acting within the CNS.

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KW - Nerve growth factor

KW - Stress

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Developmental profile of the hypothalamo-pituitary-adrenal axis response to nerve growth factor

Abstract

Keywords

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