Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells

P. J. Foreman, G. Taglialatela, G. R. Jackson, J. R. Perez‐Polo

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells. Following administration of dexamethasone (1 μM) there is a decline in NGFR mRNA expression. More importantly, administration of dexamethasone appears to block the NGF‐mediated induction of NGFR when both agents are administered simultaneously. These data support the hypothesis that glucocorticoids and NGF act in opposition in determination of the phenotype of chromaffin cells.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalJournal of Neuroscience Research
Volume31
Issue number1
DOIs
StatePublished - Jan 1992

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Keywords

  • PC 12
  • chromaffin
  • glucocorticoid

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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