Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells

P. J. Foreman, G. Taglialatela, G. R. Jackson, J. R. Perez‐Polo

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations

    Abstract

    Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells. Following administration of dexamethasone (1 μM) there is a decline in NGFR mRNA expression. More importantly, administration of dexamethasone appears to block the NGF‐mediated induction of NGFR when both agents are administered simultaneously. These data support the hypothesis that glucocorticoids and NGF act in opposition in determination of the phenotype of chromaffin cells.

    Original languageEnglish (US)
    Pages (from-to)52-57
    Number of pages6
    JournalJournal of Neuroscience Research
    Volume31
    Issue number1
    DOIs
    StatePublished - Jan 1992

    Keywords

    • PC 12
    • chromaffin
    • glucocorticoid

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience

    Fingerprint

    Dive into the research topics of 'Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells'. Together they form a unique fingerprint.

    Cite this