Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells

P. J. Foreman, Giulio Taglialatela, G. R. Jackson, J. R. Perez-Polo

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells. Following administration of dexamethasone (1 μM) there is a decline in NGFR mRNA expression. More importantly, administration of dexamethasone appears to block the NGF-mediated induction of NGFR when both agents are administered simultaneously. These data support the hypothesis that glucocorticoids and NGF act in opposition in determination of the phenotype of chromaffin cells.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalJournal of Neuroscience Research
Volume31
Issue number1
StatePublished - 1992

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Nerve Growth Factor Receptor
PC12 Cells
Nerve Growth Factor
Dexamethasone
Glucocorticoids
Chromaffin Cells
Messenger RNA
Pheochromocytoma
Phenotype

Keywords

  • chromaffin
  • glucocorticoid
  • PC12

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells. / Foreman, P. J.; Taglialatela, Giulio; Jackson, G. R.; Perez-Polo, J. R.

In: Journal of Neuroscience Research, Vol. 31, No. 1, 1992, p. 52-57.

Research output: Contribution to journalArticle

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