Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs

Leandro G. Braz, José R Cerqueira Braz, Yara M MacHado Castiglia, Pedro T Galvão Vianna, Luiz A. Vane, Norma S Pinheiro Módolo, Paulo Do Nascimento, André L. Da Silva, Michael Kinsky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that α2-agonists can produce, may determine hemodynamic alterations during aortic surgery. The interaction between dexmedetomidine (DEX), an α2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs. Twenty dogs were anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n=10, received saline infusion only, and DEX (1 μg.kg-1 load followed by 1 μg.kg-1.h -1 infusion), n=10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index (CI) and systemic oxygen transport index (DO2I) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. CI, heart rate, and DO2I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.

Original languageEnglish (US)
Pages (from-to)360-368
Number of pages9
JournalJournal of Investigative Surgery
Volume21
Issue number6
DOIs
StatePublished - 2008

Fingerprint

Dexmedetomidine
Constriction
Dogs
Kidney
Central Venous Pressure
Hemodynamics
Vascular Resistance
Arterial Pressure
Heart Rate
sevoflurane
Vasodilation
Pulmonary Artery
Anesthetics
Oxygen
Pressure
Control Groups

Keywords

  • Aortic cross-clamping
  • Dexmedetomidine
  • Dog
  • Hemodynamics
  • Oxygen transport
  • Sevoflurane

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs. / Braz, Leandro G.; Braz, José R Cerqueira; Castiglia, Yara M MacHado; Vianna, Pedro T Galvão; Vane, Luiz A.; Módolo, Norma S Pinheiro; Do Nascimento, Paulo; Da Silva, André L.; Kinsky, Michael.

In: Journal of Investigative Surgery, Vol. 21, No. 6, 2008, p. 360-368.

Research output: Contribution to journalArticle

Braz, LG, Braz, JRC, Castiglia, YMM, Vianna, PTG, Vane, LA, Módolo, NSP, Do Nascimento, P, Da Silva, AL & Kinsky, M 2008, 'Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs', Journal of Investigative Surgery, vol. 21, no. 6, pp. 360-368. https://doi.org/10.1080/08941930802440803
Braz, Leandro G. ; Braz, José R Cerqueira ; Castiglia, Yara M MacHado ; Vianna, Pedro T Galvão ; Vane, Luiz A. ; Módolo, Norma S Pinheiro ; Do Nascimento, Paulo ; Da Silva, André L. ; Kinsky, Michael. / Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs. In: Journal of Investigative Surgery. 2008 ; Vol. 21, No. 6. pp. 360-368.
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AU - Braz, Leandro G.

AU - Braz, José R Cerqueira

AU - Castiglia, Yara M MacHado

AU - Vianna, Pedro T Galvão

AU - Vane, Luiz A.

AU - Módolo, Norma S Pinheiro

AU - Do Nascimento, Paulo

AU - Da Silva, André L.

AU - Kinsky, Michael

PY - 2008

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N2 - Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that α2-agonists can produce, may determine hemodynamic alterations during aortic surgery. The interaction between dexmedetomidine (DEX), an α2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs. Twenty dogs were anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n=10, received saline infusion only, and DEX (1 μg.kg-1 load followed by 1 μg.kg-1.h -1 infusion), n=10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index (CI) and systemic oxygen transport index (DO2I) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. CI, heart rate, and DO2I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.

AB - Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that α2-agonists can produce, may determine hemodynamic alterations during aortic surgery. The interaction between dexmedetomidine (DEX), an α2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs. Twenty dogs were anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n=10, received saline infusion only, and DEX (1 μg.kg-1 load followed by 1 μg.kg-1.h -1 infusion), n=10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index (CI) and systemic oxygen transport index (DO2I) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. CI, heart rate, and DO2I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.

KW - Aortic cross-clamping

KW - Dexmedetomidine

KW - Dog

KW - Hemodynamics

KW - Oxygen transport

KW - Sevoflurane

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