Dextrorphan attenuates responses of spinothalamic tract cells in normal and nerve-injured monkeys

Susan M. Carlton, Huw Rees, Kelli Gondesen, William D. Willis

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Spinal cord N-methyl-D-aspartate (NMDA) receptors play an important role in the transmission of acute and chronic pain. The present study investigated the ability of dextrorphan (DEX), a metabolite of dextromethorphan and a clinically safe NMDA antagonist, to attenuate the responses of nociceptive spinothalamic tract (STT) neurons in anesthetized monkeys. The STT cells were recorded extracellularly in the lumbosacral enlargement and were identified by antidromic activation from the ventral posterior lateral thalamic nucleus. DEX administered through a microdialysis fiber inserted into the dorsal horn inhibited the responses of STT cells in normal animals to noxious pinch and heat stimuli. In monkeys made neuropathic by tight ligation of the L7 or S1 spinal nerve, DEX significantly attenuated the responses of STT cells to noxious pinch and heat, as well as to innocuous brushing, pressure and von Frey filament stimuli. These findings strongly suggest that DEX should be considered a potentially useful therapeutic agent for the treatment of neuropathic pain in humans.

    Original languageEnglish (US)
    Pages (from-to)169-172
    Number of pages4
    JournalNeuroscience Letters
    Volume229
    Issue number3
    DOIs
    StatePublished - Jul 4 1997

    Fingerprint

    Spinothalamic Tracts
    Dextrorphan
    Haplorhini
    Ventral Thalamic Nuclei
    Hot Temperature
    Dextromethorphan
    Spinal Nerves
    Microdialysis
    Acute Pain
    Neuralgia
    N-Methylaspartate
    N-Methyl-D-Aspartate Receptors
    Chronic Pain
    Ligation
    Spinal Cord
    Neurons
    Pressure
    Therapeutics

    Keywords

    • Allodynia
    • Glutamate antagonist
    • Hyperalgesia
    • NMDA
    • Nociception
    • Peripheral neuropathy

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Dextrorphan attenuates responses of spinothalamic tract cells in normal and nerve-injured monkeys. / Carlton, Susan M.; Rees, Huw; Gondesen, Kelli; Willis, William D.

    In: Neuroscience Letters, Vol. 229, No. 3, 04.07.1997, p. 169-172.

    Research output: Contribution to journalArticle

    Carlton, Susan M. ; Rees, Huw ; Gondesen, Kelli ; Willis, William D. / Dextrorphan attenuates responses of spinothalamic tract cells in normal and nerve-injured monkeys. In: Neuroscience Letters. 1997 ; Vol. 229, No. 3. pp. 169-172.
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