Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction

Solange de Souza Stork, Marcos Hübner, Erica Biehl, Lucineia Gainski Danielski, Sandra Bonfante, Larissa Joaquim, Tais Denicol, Thaina Cidreira, Anita Pacheco, Erick Bagio, Everton Lanzzarin, Gabriela Bernades, Mariana Pacheco de Oliveira, Larissa Espindola da Silva, Josiel M. Mack, Franciane Bobinski, Gislaine Tezza Rezin, Tatiana Barichello, Emilio Luiz Streck, Fabricia Petronilho

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Sepsis is a life-threatening organ dysfunction, which demands notable attention for its treatment, especially in view of the involvement of immunodepressed patients, as the case of patients with diabetes mellitus (DM), who constitute a population susceptible to develop infections. Thus, considering this endocrine pathology as an implicatory role on the immune system, the aim of this study was to show the relationship between this disease and sepsis on neuroinflammatory and neurochemical parameters. Levels of IL-6, IL-10, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and mitochondrial respiratory chain complexes were evaluated in the hippocampus and prefrontal cortex 24 h after sepsis by cecal ligation and perforation (CLP) in Wistar rats induced to type 1 diabetes by alloxan (150 mg/kg). It was verified that diabetes implied immune function after 24 h of sepsis, since it contributed to the increase of the inflammatory process with higher production of IL-6 and decreased levels of IL-10 only in the hippocampus. In the same brain area, a several decrease in NGF level and activity of complexes I and II of the mitochondrial respiratory chain were observed. Thus, diabetes exacerbates neuroinflammation and results in mitochondrial impairment and downregulation of NGF level in the hippocampus after sepsis.

Original languageEnglish (US)
Pages (from-to)2352-2367
Number of pages16
JournalInflammation
Volume45
Issue number6
DOIs
StatePublished - Dec 2022
Externally publishedYes

Keywords

  • Diabetes
  • Neuroinflammation
  • Oxidative stress
  • Sepsis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction'. Together they form a unique fingerprint.

Cite this