Diagnosis and quantitation of pulmonary arteriovenous malformations by factor analysis

J. Villanueva-Meyer, C. Marcus, K. Thompson, L. Philippe, I. Mena

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The diagnosis of a pulmonary arteriovenous malformation (AVM) was made by performing a computer-assisted first-pass cardiopulmonary imaging procedure using Tc-99m pertechnetate and processing the image information using factor analysis. This analytical technique is capable of separating partially overlapping structures by automatically extracting factors with different temporal behavior (time-activity curves) which correspond to functional areas without anatomic constraint. This procedure was accomplished successfully despite the presence of four-chamber enlargement, mitral stenosis and regurgitation, tricuspid regurgitation, chronic obstructive pulmonary disease and pulmonary hypertension. The magnitude of the right-to-left shunt resulting from the AVM was quantitated using both the factor analysis data and an independent Tc-99m MAA computer-assisted imaging procedure. Both methods gave comparable values.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalClinical Nuclear Medicine
Issue number2
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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