Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas

Aaron Mohanty, Vani Santosh, B. Anandh, V. R. Sastry Kolluri, M. K. Vasudev, Thimappa Hegde, S. K. Shankar

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

BACKGROUND - Stereotactic biopsies for diagnosing intracranial tuberculomas are often reported to be inconclusive, being confirmatory in only 28% of cases. We analyzed the role and diagnostic efficacy of stereotactic biopsies in the management of intracranial tuberculomas. METHODS - Twenty patients diagnosed with intracranial tuberculomas based on neuroimaging procedures underwent computerized tomography (CT) guided stereotactic biopsies for histological confirmation. In 10 patients (Group A), biopsies were obtained from the center of the lesion; in the other 10 (Group B), biopsies were obtained from both the enhancing rim and the isodense center and examined separately. The tissues were processed for paraffin sections and hematoxylin eosin staining. In addition, in the first five patients a squash smear from a small portion of the biopsy was prepared, and the cytological features of the cells were examined. All the patients received antitubercular medication and CT scans were repeated 4 months posttreatment. RESULTS - Histopathological features of the paraffin sections in 17 patients (Group A: 8, Group B: 9) were diagnostic of tuberculoma, whereas the other three revealed only chronic nonspecific inflammation. Based on the cytological features in squash smears, diagnosis could be made in one of five. In two, although the smear was not diagnostic, the histological section from the same specimen confirmed the tuberculous pathology. There was no procedural morbidity or mortality. One patient had a small asymptomatic hematoma at the biopsy site. Three patients died during the follow-up period, due to secondary complications of tuberculosis. Repeat CT scans during follow-up after antituberculous treatment confirmed the reduction in the size of the lesion in 15/17 patients.CONCLUSIONThe high positive yield of stereotactic biopsies in diagnosing tuberculomas argues for their inclusion in the management protocol for tuberculous mass lesions. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalSurgical Neurology
Volume52
Issue number3
DOIs
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Intracranial Tuberculoma
Biopsy
Tuberculoma
Cucurbita
Tomography
Paraffin
Hematoxylin
Eosine Yellowish-(YS)
Neuroimaging
Hematoma
Tuberculosis
Pathology
Staining and Labeling
Inflammation
Morbidity

Keywords

  • Management
  • Stereotactic biopsy
  • Stereotaxy
  • Tuberculoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Mohanty, A., Santosh, V., Anandh, B., Sastry Kolluri, V. R., Vasudev, M. K., Hegde, T., & Shankar, S. K. (1999). Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas. Surgical Neurology, 52(3), 252-258. https://doi.org/10.1016/S0090-3019(99)00089-0

Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas. / Mohanty, Aaron; Santosh, Vani; Anandh, B.; Sastry Kolluri, V. R.; Vasudev, M. K.; Hegde, Thimappa; Shankar, S. K.

In: Surgical Neurology, Vol. 52, No. 3, 09.1999, p. 252-258.

Research output: Contribution to journalArticle

Mohanty, A, Santosh, V, Anandh, B, Sastry Kolluri, VR, Vasudev, MK, Hegde, T & Shankar, SK 1999, 'Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas', Surgical Neurology, vol. 52, no. 3, pp. 252-258. https://doi.org/10.1016/S0090-3019(99)00089-0
Mohanty A, Santosh V, Anandh B, Sastry Kolluri VR, Vasudev MK, Hegde T et al. Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas. Surgical Neurology. 1999 Sep;52(3):252-258. https://doi.org/10.1016/S0090-3019(99)00089-0
Mohanty, Aaron ; Santosh, Vani ; Anandh, B. ; Sastry Kolluri, V. R. ; Vasudev, M. K. ; Hegde, Thimappa ; Shankar, S. K. / Diagnostic efficacy of stereotactic biopsies in intracranial tuberculomas. In: Surgical Neurology. 1999 ; Vol. 52, No. 3. pp. 252-258.
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AB - BACKGROUND - Stereotactic biopsies for diagnosing intracranial tuberculomas are often reported to be inconclusive, being confirmatory in only 28% of cases. We analyzed the role and diagnostic efficacy of stereotactic biopsies in the management of intracranial tuberculomas. METHODS - Twenty patients diagnosed with intracranial tuberculomas based on neuroimaging procedures underwent computerized tomography (CT) guided stereotactic biopsies for histological confirmation. In 10 patients (Group A), biopsies were obtained from the center of the lesion; in the other 10 (Group B), biopsies were obtained from both the enhancing rim and the isodense center and examined separately. The tissues were processed for paraffin sections and hematoxylin eosin staining. In addition, in the first five patients a squash smear from a small portion of the biopsy was prepared, and the cytological features of the cells were examined. All the patients received antitubercular medication and CT scans were repeated 4 months posttreatment. RESULTS - Histopathological features of the paraffin sections in 17 patients (Group A: 8, Group B: 9) were diagnostic of tuberculoma, whereas the other three revealed only chronic nonspecific inflammation. Based on the cytological features in squash smears, diagnosis could be made in one of five. In two, although the smear was not diagnostic, the histological section from the same specimen confirmed the tuberculous pathology. There was no procedural morbidity or mortality. One patient had a small asymptomatic hematoma at the biopsy site. Three patients died during the follow-up period, due to secondary complications of tuberculosis. Repeat CT scans during follow-up after antituberculous treatment confirmed the reduction in the size of the lesion in 15/17 patients.CONCLUSIONThe high positive yield of stereotactic biopsies in diagnosing tuberculomas argues for their inclusion in the management protocol for tuberculous mass lesions. Copyright (C) 1999 Elsevier Science Inc.

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