Diastolic dysfunction and COPD exacerbation

Ghassan H. Abusaid, Alejandro Barbagelata, Enrique Tuero, Asif Mahmood, Gulshan Sharma

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) exacerbation is a frequent cause of hospital admissions. In one-third of patients, exacerbations have no known cause. We studied whether the presence of diastolic dysfunction (DD) in this subgroup of patients is associated with longer duration of hospitalization and more frequent exacerbations. Methods: Retrospective chart review of 139 patients with COPD, 84 with DD, and 55 with normal diastolic function hospitalized for acute COPD exacerbation between November 2004 and December 2007 was done. Diastolic dysfunction was defined by the presence of relaxation. filling, or distensibilily abnormalities of the left ventricle on transthoracic echocardiogram. Results: Patients wilh DD had increased length of stay compared with patients without DD (mean: 4.02 ± 1.8 days vs 3.24 ± 1.20 days; P = 0.005). Patients with DD had 1.28 exacerbations requiring hospitalization per patient-year compared with 0.67 in the normal diastolic function group (P = 0.0067). Conclusions: Patients with COPD and DD had prolonged and more frequent hospitalizations for COPD exacerbations. These findings suggest that DD, a surrogate for increased left ventricular filling pressure, is common in patients with COPD exacerbations and may be associated with increased frequency of hospitalization.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalPostgraduate Medicine
Volume121
Issue number4
DOIs
StatePublished - Jul 2009

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Chronic Obstructive Pulmonary Disease
Disease Progression
Hospitalization
Ventricular Pressure
Heart Ventricles
Length of Stay

Keywords

  • Congestive heart failure
  • COPD
  • Diastolic dysfunction
  • Diastolic heart failure
  • Length of stay
  • Pulmonary hypertension
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Abusaid, G. H., Barbagelata, A., Tuero, E., Mahmood, A., & Sharma, G. (2009). Diastolic dysfunction and COPD exacerbation. Postgraduate Medicine, 121(4), 76-81. https://doi.org/10.3810/pgm.2009.07.2033

Diastolic dysfunction and COPD exacerbation. / Abusaid, Ghassan H.; Barbagelata, Alejandro; Tuero, Enrique; Mahmood, Asif; Sharma, Gulshan.

In: Postgraduate Medicine, Vol. 121, No. 4, 07.2009, p. 76-81.

Research output: Contribution to journalArticle

Abusaid, GH, Barbagelata, A, Tuero, E, Mahmood, A & Sharma, G 2009, 'Diastolic dysfunction and COPD exacerbation', Postgraduate Medicine, vol. 121, no. 4, pp. 76-81. https://doi.org/10.3810/pgm.2009.07.2033
Abusaid, Ghassan H. ; Barbagelata, Alejandro ; Tuero, Enrique ; Mahmood, Asif ; Sharma, Gulshan. / Diastolic dysfunction and COPD exacerbation. In: Postgraduate Medicine. 2009 ; Vol. 121, No. 4. pp. 76-81.
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