Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance

Justin R. Gregg, Jiali Zheng, David Lopez, Chad Reichard, Gladys Browman, Brian Chapin, Jeri Kim, John Davis, Carrie R. Daniel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: High diet quality may support a metabolic and anti-inflammatory state less conducive to tumour progression. We prospectively investigated diet quality in relation to Gleason grade progression among localised prostate cancer patients on active surveillance, a clinical management strategy of disease monitoring and delayed intervention. Methods: Men with newly diagnosed Gleason score 6 or 7 prostate cancer enroled on a biennial monitoring regimen. Patients completed a food frequency questionnaire (FFQ) at baseline (n = 411) and first 6-month follow-up (n = 263). Cox proportional hazards models were fitted to evaluate multivariable-adjusted associations of diet quality [defined via the Healthy Eating Index (HEI)-2015] with Gleason grade progression. Results: After a median follow-up of 36 months, 76 men progressed. Following adjustment for clinicopathologic factors, we observed a suggestive inverse association between baseline diet quality and Gleason grade progression [hazard ratio (HR) and 95% confidence interval (CI) for the highest vs. the lowest HEI-2015 tertile: 0.59 (0.32–1.08); P trend = 0.06]. We observed no associations with diet quality at 6-month follow-up, nor change in diet quality from baseline. Conclusions: In localised prostate cancer patients on surveillance, higher diet quality or conformance with United States dietary guidelines at enrolment may lower risk of Gleason grade progression, though additional confirmatory research is needed.

Original languageEnglish (US)
Pages (from-to)466-471
Number of pages6
JournalBritish Journal of Cancer
Volume120
Issue number4
DOIs
StatePublished - Feb 19 2019

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Prostatic Neoplasms
Diet
Nutrition Policy
Neoplasm Grading
Disease Management
Proportional Hazards Models
Anti-Inflammatory Agents
Confidence Intervals
Food
Research
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance. / Gregg, Justin R.; Zheng, Jiali; Lopez, David; Reichard, Chad; Browman, Gladys; Chapin, Brian; Kim, Jeri; Davis, John; Daniel, Carrie R.

In: British Journal of Cancer, Vol. 120, No. 4, 19.02.2019, p. 466-471.

Research output: Contribution to journalArticle

Gregg, JR, Zheng, J, Lopez, D, Reichard, C, Browman, G, Chapin, B, Kim, J, Davis, J & Daniel, CR 2019, 'Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance', British Journal of Cancer, vol. 120, no. 4, pp. 466-471. https://doi.org/10.1038/s41416-019-0380-2
Gregg, Justin R. ; Zheng, Jiali ; Lopez, David ; Reichard, Chad ; Browman, Gladys ; Chapin, Brian ; Kim, Jeri ; Davis, John ; Daniel, Carrie R. / Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance. In: British Journal of Cancer. 2019 ; Vol. 120, No. 4. pp. 466-471.
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abstract = "Background: High diet quality may support a metabolic and anti-inflammatory state less conducive to tumour progression. We prospectively investigated diet quality in relation to Gleason grade progression among localised prostate cancer patients on active surveillance, a clinical management strategy of disease monitoring and delayed intervention. Methods: Men with newly diagnosed Gleason score 6 or 7 prostate cancer enroled on a biennial monitoring regimen. Patients completed a food frequency questionnaire (FFQ) at baseline (n = 411) and first 6-month follow-up (n = 263). Cox proportional hazards models were fitted to evaluate multivariable-adjusted associations of diet quality [defined via the Healthy Eating Index (HEI)-2015] with Gleason grade progression. Results: After a median follow-up of 36 months, 76 men progressed. Following adjustment for clinicopathologic factors, we observed a suggestive inverse association between baseline diet quality and Gleason grade progression [hazard ratio (HR) and 95{\%} confidence interval (CI) for the highest vs. the lowest HEI-2015 tertile: 0.59 (0.32–1.08); P trend = 0.06]. We observed no associations with diet quality at 6-month follow-up, nor change in diet quality from baseline. Conclusions: In localised prostate cancer patients on surveillance, higher diet quality or conformance with United States dietary guidelines at enrolment may lower risk of Gleason grade progression, though additional confirmatory research is needed.",
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