Abstract
This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-340 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 95 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Dec 19 1988 |
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Keywords
- Calcitonin gene-related peptide, Calcium
- Sensory afferent
- Spinal cord
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat. / DiPette, Donald J.; Westlund, Karin N.; Holland, O. Bryan.
In: Neuroscience Letters, Vol. 95, No. 1-3, 19.12.1988, p. 335-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat
AU - DiPette, Donald J.
AU - Westlund, Karin N.
AU - Holland, O. Bryan
PY - 1988/12/19
Y1 - 1988/12/19
N2 - This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.
AB - This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.
KW - Calcitonin gene-related peptide, Calcium
KW - Sensory afferent
KW - Spinal cord
UR - http://www.scopus.com/inward/record.url?scp=0023761784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023761784&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(88)90681-7
DO - 10.1016/0304-3940(88)90681-7
M3 - Article
C2 - 3265772
AN - SCOPUS:0023761784
VL - 95
SP - 335
EP - 340
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-3
ER -