Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat

Donald J. DiPette; Karin N. Westlund; O. Bryan Holland

doi:10.1016/0304-3940(88)90681-7

Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat

Donald J. DiPette, Karin N. Westlund, O. Bryan Holland

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.

Original language	English (US)
Pages (from-to)	335-340
Number of pages	6
Journal	Neuroscience Letters
Volume	95
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3940(88)90681-7
State	Published - Dec 19 1988

Fingerprint

Keywords

Calcitonin gene-related peptide, Calcium
Sensory afferent
Spinal cord

ASJC Scopus subject areas

Neuroscience(all)

Cite this

DiPette, D. J., Westlund, K. N., & Holland, O. B. (1988). Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat. Neuroscience Letters, 95(1-3), 335-340. https://doi.org/10.1016/0304-3940(88)90681-7

@article{0f53051d14884e668f747498a285b567,

title = "Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat",

abstract = "This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.",

keywords = "Calcitonin gene-related peptide, Calcium, Sensory afferent, Spinal cord",

author = "DiPette, {Donald J.} and Westlund, {Karin N.} and Holland, {O. Bryan}",

year = "1988",

month = dec

day = "19",

doi = "10.1016/0304-3940(88)90681-7",

language = "English (US)",

volume = "95",

pages = "335--340",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Dietary calcium modulates spinal cord content of calcitonin gene-related peptide in the rat

AU - DiPette, Donald J.

AU - Westlund, Karin N.

AU - Holland, O. Bryan

PY - 1988/12/19

Y1 - 1988/12/19

N2 - This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.

AB - This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.

KW - Calcitonin gene-related peptide, Calcium

KW - Sensory afferent

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0023761784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023761784&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(88)90681-7

DO - 10.1016/0304-3940(88)90681-7

M3 - Article

C2 - 3265772

AN - SCOPUS:0023761784

VL - 95

SP - 335

EP - 340

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-3

ER -

Access to Document

10.1016/0304-3940(88)90681-7