@article{a1472b7dbd5c49e7b753ad24f51d21f4,
title = "Dietary fatty acids modulate host bacteriocidal response, microbial translocation and survival following blood transfusion and thermal injury",
abstract = "The effect of dietary lipids on bacterial translocation, killing of translocated organisms and host survival was studied in a burned animal model. Balb/c mice were fed with one of the three experimental AIN-76A diets (containing 15% of energy from fish oil, safflower oil or a 50:50 mixture), AIN-76A without added lipids or a nonpurified stock diet. All animals were transfused on day 10. On day 15, the animals were gavaged with 1010 14C radiolabelled Escherichia coli and given a 20% burn injury. Survival was 84% in the fish oil group versus 36% in the safflower oil and 50:50 diet groups, and 25% and 20% in the two control groups (P < 0.0001). The numbers of viable translocating bacteria were reduced in all tested organs in the fish oil groups compared to the other groups. It is concluded that a diet enriched in fish oil has beneficial effects during gut-derived sepsis.",
author = "L. Gianotti and Alexander, {J. W.} and T. Eaves-Pyles and R. Fukushima",
note = "Funding Information: All animals were quarantined for 1 week to allow for adaptation to the new environmental conditions and to exclude animals with preexisting disease. During this period, the animals were provided food (Rodent Laboratory Chow 5001, Purina Mills Inc., St Louis, MO) and water ad libitum until the start of the experiments. The experimental protocols were approved by the University of Cincinnati Animal Care and Use Committee and the animals were maintained in a facility approved by the American Association for the Accreditation of Laboratory Animal Care. In conducting the described research, the investigators adhered to the Guide for the Care and the Use of Laboratory Animals as set forth by the Committee on the Care and Use of Laboratory Animals, National Research Council, and United States Department of Health and Human Services, National Institutes of Health. The animals were killed using an overdose of methoxyflurane anesthesia and cervical dislocation or by carbon dioxide inhalation according to the Guide for the Care and Use of Laboratory Animals.",
year = "1996",
doi = "10.1016/S0261-5614(96)80002-1",
language = "English (US)",
volume = "15",
pages = "291--296",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "6",
}