Dietary fatty acids modulate host bacteriocidal response, microbial translocation and survival following blood transfusion and thermal injury

L. Gianotti, J. W. Alexander, Tonyia Eaves-Pyles, R. Fukushima

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effect of dietary lipids on bacterial translocation, killing of translocated organisms and host survival was studied in a burned animal model. Balb/c mice were fed with one of the three experimental AIN-76A diets (containing 15% of energy from fish oil, safflower oil or a 50:50 mixture), AIN76A without added lipids or a nonpurified stock diet. All animals were transfused on day 10. On day 15, the animals were gavaged with 1010 14C radiolabelled Escherichia coli and given a 20% burn injury. Survival was 84% in the fish oil group versus 36% in the safflower oil and 50:50 diet groups, and 25% and 20% in the two control groups (P< 0.0001). The numbers of viable translocating bacteria were reduced in all tested organs in the fish oil groups compared to the other groups. It is concluded that a diet enriched in fish oil has beneficial effects during gut-derived sepsis.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalClinical Nutrition
Volume15
Issue number6
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Fish Oils
Blood Transfusion
Fatty Acids
Hot Temperature
Safflower Oil
Diet
Wounds and Injuries
Bacterial Translocation
Lipids
Sepsis
Animal Models
Escherichia coli
Bacteria
Control Groups

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)
  • Medicine (miscellaneous)

Cite this

Dietary fatty acids modulate host bacteriocidal response, microbial translocation and survival following blood transfusion and thermal injury. / Gianotti, L.; Alexander, J. W.; Eaves-Pyles, Tonyia; Fukushima, R.

In: Clinical Nutrition, Vol. 15, No. 6, 1996, p. 291-296.

Research output: Contribution to journalArticle

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