Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice

Hui Wang, Yansong Xue, Hanying Zhang, Yan Huang, Guan Yang, Min Du, Mei Jun Zhu

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Grape seed extract (GSE) is a by-product of the wine industry, with abundant polyphenolic compounds known for their anti-inflammatory and anti-oxidative effects. Using IL10-deficient mice (IL10KO), here we showed that GSE (1% of dry feed weight) ameliorated inflammatory bowel disease indices, increased colonic goblet cell numbers and decreased myeloperoxidase levels in the large intestine. Concomitantly, GSE supplementation attenuated inflammation, decreased the expression of pore forming tight junction protein claudin2, and increased levels of Lactobacilli and Bacteroides in the gut microbiota of IL10KO mice. In summary, our study shows that GSE has protective roles on inflammatory bowel disease through altering gut inflammation, tight junction protein expression, and gut microbiota composition.

Original languageEnglish (US)
Pages (from-to)2253-2257
Number of pages5
JournalMolecular Nutrition and Food Research
Volume57
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Epithelium
  • Grape seed extract
  • IL-10
  • Inflammatory bowel disease
  • Intestine
  • Microbiota

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

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