Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients

A. D. McNaghten, Debra L. Hanson, Mark S. Dworkin, Jeffrey L. Jones, Jane Turner, Amy Wohl, David Cohn, Arthur Davidson, Cornelius Rietmeijer, Julia Gable, Melanie Thompson, Stephanie Broyles, Anne Morse, Eve Mokotoff, Linda Wotring, Judy Sackoff, Maria De los Angeles Gomez, Robert Hunter, Jose Otero, Sandra MirandaSharon Melville, Sylvia Odem, Philip Keiser, Wes McNeely, Kaye Reynolds, Susan Buskin, Sharon Hopkins

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The objective of this study was to determine factors associated with prescription of highly active antiretroviral therapy (HAART). The authors observed 9530 patients eligible for antiretroviral therapy (ART) in more than 100 hospitals and clinics in 10 US cities. Multiple logistic regression analysis was used to assess factors associated with HAART prescription, stratifying patients by no history versus history of ART to assess the association between prescription and CD4, viral load, and outpatient visits. Overall, female gender (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.60-0.76) and alcoholism (OR, 0.85; 95% CI, 0.74-0.99) were associated with decreased likelihood of HAART prescription. Enrollment at a private facility (OR, 1.33; 95% CI, 1.14-1.56), heterosexual exposure (OR, 1.34; 95% CI, 1.13-1.58), and Hispanic ethnicity (OR, 1.19; 95% CI, 1.04-1.37) were associated with prescription. For patients with no history of prescribed ART, CD4 <500 cells/μL (OR, 3.94; 95% CI, 2.02-7.66), and high viral load were associated with increased likelihood of prescription; for patients with history of ART prescription, those whose outpatient visits averaged ≥2 per 6-month interval (OR, 1.30; 95% CI, 1.10-1.54) were more likely and those with high viral load were less likely to be prescribed HAART (OR, 0.50; 95% CI, 0.44-0.56). The authors found differences in HAART prescription by gender, race, exposure mode, alcoholism, and provider type for all patients, by CD4 and viral load for patients with no history of ART prescription, and by average number of outpatient visits and viral load for patients with history of ART prescription.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume32
Issue number5
DOIs
StatePublished - Apr 15 2003
Externally publishedYes

Fingerprint

Prescriptions
HIV
Odds Ratio
Confidence Intervals
Highly Active Antiretroviral Therapy
Viral Load
Therapeutics
Outpatients
Alcoholism
Heterosexuality
Hispanic Americans
Logistic Models
History
Regression Analysis

Keywords

  • Antiretroviral therapy
  • HAART prescription
  • Highly active antiretroviral therapy (HAART)

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

McNaghten, A. D., Hanson, D. L., Dworkin, M. S., Jones, J. L., Turner, J., Wohl, A., ... Hopkins, S. (2003). Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes, 32(5), 499-505. https://doi.org/10.1097/00126334-200304150-00006

Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients. / McNaghten, A. D.; Hanson, Debra L.; Dworkin, Mark S.; Jones, Jeffrey L.; Turner, Jane; Wohl, Amy; Cohn, David; Davidson, Arthur; Rietmeijer, Cornelius; Gable, Julia; Thompson, Melanie; Broyles, Stephanie; Morse, Anne; Mokotoff, Eve; Wotring, Linda; Sackoff, Judy; De los Angeles Gomez, Maria; Hunter, Robert; Otero, Jose; Miranda, Sandra; Melville, Sharon; Odem, Sylvia; Keiser, Philip; McNeely, Wes; Reynolds, Kaye; Buskin, Susan; Hopkins, Sharon.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 32, No. 5, 15.04.2003, p. 499-505.

Research output: Contribution to journalArticle

McNaghten, AD, Hanson, DL, Dworkin, MS, Jones, JL, Turner, J, Wohl, A, Cohn, D, Davidson, A, Rietmeijer, C, Gable, J, Thompson, M, Broyles, S, Morse, A, Mokotoff, E, Wotring, L, Sackoff, J, De los Angeles Gomez, M, Hunter, R, Otero, J, Miranda, S, Melville, S, Odem, S, Keiser, P, McNeely, W, Reynolds, K, Buskin, S & Hopkins, S 2003, 'Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients', Journal of Acquired Immune Deficiency Syndromes, vol. 32, no. 5, pp. 499-505. https://doi.org/10.1097/00126334-200304150-00006
McNaghten, A. D. ; Hanson, Debra L. ; Dworkin, Mark S. ; Jones, Jeffrey L. ; Turner, Jane ; Wohl, Amy ; Cohn, David ; Davidson, Arthur ; Rietmeijer, Cornelius ; Gable, Julia ; Thompson, Melanie ; Broyles, Stephanie ; Morse, Anne ; Mokotoff, Eve ; Wotring, Linda ; Sackoff, Judy ; De los Angeles Gomez, Maria ; Hunter, Robert ; Otero, Jose ; Miranda, Sandra ; Melville, Sharon ; Odem, Sylvia ; Keiser, Philip ; McNeely, Wes ; Reynolds, Kaye ; Buskin, Susan ; Hopkins, Sharon. / Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients. In: Journal of Acquired Immune Deficiency Syndromes. 2003 ; Vol. 32, No. 5. pp. 499-505.
@article{39a6413690c7421a86c41b57df58e7ca,
title = "Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients",
abstract = "The objective of this study was to determine factors associated with prescription of highly active antiretroviral therapy (HAART). The authors observed 9530 patients eligible for antiretroviral therapy (ART) in more than 100 hospitals and clinics in 10 US cities. Multiple logistic regression analysis was used to assess factors associated with HAART prescription, stratifying patients by no history versus history of ART to assess the association between prescription and CD4, viral load, and outpatient visits. Overall, female gender (odds ratio [OR], 0.68; 95{\%} confidence interval [CI], 0.60-0.76) and alcoholism (OR, 0.85; 95{\%} CI, 0.74-0.99) were associated with decreased likelihood of HAART prescription. Enrollment at a private facility (OR, 1.33; 95{\%} CI, 1.14-1.56), heterosexual exposure (OR, 1.34; 95{\%} CI, 1.13-1.58), and Hispanic ethnicity (OR, 1.19; 95{\%} CI, 1.04-1.37) were associated with prescription. For patients with no history of prescribed ART, CD4 <500 cells/μL (OR, 3.94; 95{\%} CI, 2.02-7.66), and high viral load were associated with increased likelihood of prescription; for patients with history of ART prescription, those whose outpatient visits averaged ≥2 per 6-month interval (OR, 1.30; 95{\%} CI, 1.10-1.54) were more likely and those with high viral load were less likely to be prescribed HAART (OR, 0.50; 95{\%} CI, 0.44-0.56). The authors found differences in HAART prescription by gender, race, exposure mode, alcoholism, and provider type for all patients, by CD4 and viral load for patients with no history of ART prescription, and by average number of outpatient visits and viral load for patients with history of ART prescription.",
keywords = "Antiretroviral therapy, HAART prescription, Highly active antiretroviral therapy (HAART)",
author = "McNaghten, {A. D.} and Hanson, {Debra L.} and Dworkin, {Mark S.} and Jones, {Jeffrey L.} and Jane Turner and Amy Wohl and David Cohn and Arthur Davidson and Cornelius Rietmeijer and Julia Gable and Melanie Thompson and Stephanie Broyles and Anne Morse and Eve Mokotoff and Linda Wotring and Judy Sackoff and {De los Angeles Gomez}, Maria and Robert Hunter and Jose Otero and Sandra Miranda and Sharon Melville and Sylvia Odem and Philip Keiser and Wes McNeely and Kaye Reynolds and Susan Buskin and Sharon Hopkins",
year = "2003",
month = "4",
day = "15",
doi = "10.1097/00126334-200304150-00006",
language = "English (US)",
volume = "32",
pages = "499--505",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Differences in prescription of antiretroviral therapy in a large cohort of HIV-infected patients

AU - McNaghten, A. D.

AU - Hanson, Debra L.

AU - Dworkin, Mark S.

AU - Jones, Jeffrey L.

AU - Turner, Jane

AU - Wohl, Amy

AU - Cohn, David

AU - Davidson, Arthur

AU - Rietmeijer, Cornelius

AU - Gable, Julia

AU - Thompson, Melanie

AU - Broyles, Stephanie

AU - Morse, Anne

AU - Mokotoff, Eve

AU - Wotring, Linda

AU - Sackoff, Judy

AU - De los Angeles Gomez, Maria

AU - Hunter, Robert

AU - Otero, Jose

AU - Miranda, Sandra

AU - Melville, Sharon

AU - Odem, Sylvia

AU - Keiser, Philip

AU - McNeely, Wes

AU - Reynolds, Kaye

AU - Buskin, Susan

AU - Hopkins, Sharon

PY - 2003/4/15

Y1 - 2003/4/15

N2 - The objective of this study was to determine factors associated with prescription of highly active antiretroviral therapy (HAART). The authors observed 9530 patients eligible for antiretroviral therapy (ART) in more than 100 hospitals and clinics in 10 US cities. Multiple logistic regression analysis was used to assess factors associated with HAART prescription, stratifying patients by no history versus history of ART to assess the association between prescription and CD4, viral load, and outpatient visits. Overall, female gender (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.60-0.76) and alcoholism (OR, 0.85; 95% CI, 0.74-0.99) were associated with decreased likelihood of HAART prescription. Enrollment at a private facility (OR, 1.33; 95% CI, 1.14-1.56), heterosexual exposure (OR, 1.34; 95% CI, 1.13-1.58), and Hispanic ethnicity (OR, 1.19; 95% CI, 1.04-1.37) were associated with prescription. For patients with no history of prescribed ART, CD4 <500 cells/μL (OR, 3.94; 95% CI, 2.02-7.66), and high viral load were associated with increased likelihood of prescription; for patients with history of ART prescription, those whose outpatient visits averaged ≥2 per 6-month interval (OR, 1.30; 95% CI, 1.10-1.54) were more likely and those with high viral load were less likely to be prescribed HAART (OR, 0.50; 95% CI, 0.44-0.56). The authors found differences in HAART prescription by gender, race, exposure mode, alcoholism, and provider type for all patients, by CD4 and viral load for patients with no history of ART prescription, and by average number of outpatient visits and viral load for patients with history of ART prescription.

AB - The objective of this study was to determine factors associated with prescription of highly active antiretroviral therapy (HAART). The authors observed 9530 patients eligible for antiretroviral therapy (ART) in more than 100 hospitals and clinics in 10 US cities. Multiple logistic regression analysis was used to assess factors associated with HAART prescription, stratifying patients by no history versus history of ART to assess the association between prescription and CD4, viral load, and outpatient visits. Overall, female gender (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.60-0.76) and alcoholism (OR, 0.85; 95% CI, 0.74-0.99) were associated with decreased likelihood of HAART prescription. Enrollment at a private facility (OR, 1.33; 95% CI, 1.14-1.56), heterosexual exposure (OR, 1.34; 95% CI, 1.13-1.58), and Hispanic ethnicity (OR, 1.19; 95% CI, 1.04-1.37) were associated with prescription. For patients with no history of prescribed ART, CD4 <500 cells/μL (OR, 3.94; 95% CI, 2.02-7.66), and high viral load were associated with increased likelihood of prescription; for patients with history of ART prescription, those whose outpatient visits averaged ≥2 per 6-month interval (OR, 1.30; 95% CI, 1.10-1.54) were more likely and those with high viral load were less likely to be prescribed HAART (OR, 0.50; 95% CI, 0.44-0.56). The authors found differences in HAART prescription by gender, race, exposure mode, alcoholism, and provider type for all patients, by CD4 and viral load for patients with no history of ART prescription, and by average number of outpatient visits and viral load for patients with history of ART prescription.

KW - Antiretroviral therapy

KW - HAART prescription

KW - Highly active antiretroviral therapy (HAART)

UR - http://www.scopus.com/inward/record.url?scp=0037446439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037446439&partnerID=8YFLogxK

U2 - 10.1097/00126334-200304150-00006

DO - 10.1097/00126334-200304150-00006

M3 - Article

C2 - 12679701

AN - SCOPUS:0037446439

VL - 32

SP - 499

EP - 505

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 5

ER -