Differences in the accumulation of lithium in human neuroblastoma and glioma cells in tissue culture

R. P. Saneto, J. R. Perez-Polo

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    A human neuronal and a human glioma line were used to study lithium (Li) transport mechanisms and kinetics of influx. We demonstrated that, unlike the human erythrocyte or clonal neuroblastoma cell SY5Y, the cloned glioma cell line A1B1 had neither a ouabain or phloretin-sensitive component of Li influx. Furthermore, glioma cells were shown to accumulate significantly more (4 fold) Li and at an apparently faster rate when compared to the neuroblastoma cell, SY5Y, over the same time period. Thus, these two clones may be a better in vitro model system for the study of Li transport components native to the human central nervous system as compared to erythrocytes. This study also suggests that glial tissue may preferentially accumulate Li and in this way control the levels of extracellular Li surrounding some neurons.

    Original languageEnglish (US)
    Pages (from-to)413-418
    Number of pages6
    JournalJournal of Neuroscience Research
    Volume7
    Issue number4
    StatePublished - 1982

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    Neuroblastoma
    Lithium
    Glioma
    Erythrocytes
    Phloretin
    Ouabain
    Neuroglia
    Central Nervous System
    Clone Cells
    Neurons
    Cell Line

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Differences in the accumulation of lithium in human neuroblastoma and glioma cells in tissue culture. / Saneto, R. P.; Perez-Polo, J. R.

    In: Journal of Neuroscience Research, Vol. 7, No. 4, 1982, p. 413-418.

    Research output: Contribution to journalArticle

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