Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson; Gösta Karlsson; Kaj Blennow; Markus Heilig; Rolf Ekman

doi:10.1016/0196-9781(96)00013-7

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson, Gösta Karlsson, Kaj Blennow, Markus Heilig, Rolf Ekman

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

Original language	English (US)
Pages (from-to)	359-362
Number of pages	4
Journal	Peptides
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(96)00013-7
State	Published - 1996
Externally published	Yes

Keywords

Depression
HPLC
Human platelets
Neuropeptide Y
Peptide fragments
Radioimmunoassay

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(96)00013-7

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abstract = "In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.",

keywords = "Depression, HPLC, Human platelets, Neuropeptide Y, Peptide fragments, Radioimmunoassay",

author = "Carol Nilsson and G{\"o}sta Karlsson and Kaj Blennow and Markus Heilig and Rolf Ekman",

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AU - Nilsson, Carol

AU - Karlsson, Gösta

AU - Blennow, Kaj

AU - Heilig, Markus

AU - Ekman, Rolf

PY - 1996

Y1 - 1996

N2 - In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

AB - In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

KW - Depression

KW - HPLC

KW - Human platelets

KW - Neuropeptide Y

KW - Peptide fragments

KW - Radioimmunoassay

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AN - SCOPUS:0029938835

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JO - Peptides

JF - Peptides

IS - 3

ER -

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Abstract

Keywords

ASJC Scopus subject areas

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