Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson, Gösta Karlsson, Kaj Blennow, Markus Heilig, Rolf Ekman

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalPeptides
Volume17
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

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Neuropeptide Y
Platelets
Volunteers
Blood Platelets
Plasmas
High Pressure Liquid Chromatography

Keywords

  • Depression
  • HPLC
  • Human platelets
  • Neuropeptide Y
  • Peptide fragments
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients. / Nilsson, Carol; Karlsson, Gösta; Blennow, Kaj; Heilig, Markus; Ekman, Rolf.

In: Peptides, Vol. 17, No. 3, 1996, p. 359-362.

Research output: Contribution to journalArticle

Nilsson, Carol ; Karlsson, Gösta ; Blennow, Kaj ; Heilig, Markus ; Ekman, Rolf. / Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients. In: Peptides. 1996 ; Vol. 17, No. 3. pp. 359-362.
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