Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson, Gösta Karlsson, Kaj Blennow, Markus Heilig, Rolf Ekman

Research output: Contribution to journalArticle

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Abstract

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalPeptides
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Depression
  • HPLC
  • Human platelets
  • Neuropeptide Y
  • Peptide fragments
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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