Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson; Gösta Karlsson; Kaj Blennow; Markus Heilig; Rolf Ekman

doi:10.1016/0196-9781(96)00013-7

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Carol Nilsson
, Gösta Karlsson
, Kaj Blennow
, Markus Heilig
, Rolf Ekman

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

Original language	English (US)
Pages (from-to)	359-362
Number of pages	4
Journal	Peptides
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(96)00013-7
State	Published - 1996
Externally published	Yes

Keywords

Depression
HPLC
Human platelets
Neuropeptide Y
Peptide fragments
Radioimmunoassay

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(96)00013-7

Cite this

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abstract = "In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.",

keywords = "Depression, HPLC, Human platelets, Neuropeptide Y, Peptide fragments, Radioimmunoassay",

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year = "1996",

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volume = "17",

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AU - Nilsson, Carol

AU - Karlsson, Gösta

AU - Blennow, Kaj

AU - Heilig, Markus

AU - Ekman, Rolf

PY - 1996

Y1 - 1996

N2 - In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

AB - In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

KW - Depression

KW - HPLC

KW - Human platelets

KW - Neuropeptide Y

KW - Peptide fragments

KW - Radioimmunoassay

UR - https://www.scopus.com/pages/publications/0029938835

UR - https://www.scopus.com/pages/publications/0029938835#tab=citedBy

U2 - 10.1016/0196-9781(96)00013-7

DO - 10.1016/0196-9781(96)00013-7

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AN - SCOPUS:0029938835

SN - 0196-9781

VL - 17

SP - 359

EP - 362

JO - Peptides

JF - Peptides

IS - 3

ER -

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Abstract

Keywords

ASJC Scopus subject areas

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