Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain

W. J. Friedman, C. F. Ibáñez, F. Hallböök, H. Persson, L. D. Cain, C. F. Dreyfus, I. B. Black

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

The neurotrophin gene family, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4/NT-5, supports the survival of distinct peripheral neurons, however, actions upon central neurons are relatively undefined. In this study we have compared different neurotrophins in the regulation of neuronal survival and function using dissociated embryonic cell cultures from two brain regions, the basal forebrain (BF) and locus coeruleus (LC). In the BF, NGF increased choline acetyl transferase (ChAT) activity, but did not influence cholinergic cell survival. In contrast to NGF, BDNF, NT-3, and the novel neurotrophin, NT-4, all increased ChAT activity and cholinergic cell survival. We also examined embryonic LC neurons in culture. LC neurons are unresponsive to NGF. In contrast, NT-3 and NT-4 elicited significant increases in survival of noradrenergic LC neurons, the first demonstration of trophic effects in this critical brain region. Identification of factors supporting coerulcal and basal forebrain neuronal survival may provide insight into mechanisms mediating degeneration of these disparate structures in clinical disorders.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalExperimental Neurology
Volume119
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

Fingerprint

Locus Coeruleus
Nerve Growth Factors
Nerve Growth Factor
Neurotrophin 3
Neurons
Brain-Derived Neurotrophic Factor
Transferases
Choline
Cholinergic Agents
Cell Survival
Brain
Cell Culture Techniques
Basal Forebrain
neurotrophin 4
Genes

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Friedman, W. J., Ibáñez, C. F., Hallböök, F., Persson, H., Cain, L. D., Dreyfus, C. F., & Black, I. B. (1993). Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain. Experimental Neurology, 119(1), 72-78. https://doi.org/10.1006/exnr.1993.1007

Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain. / Friedman, W. J.; Ibáñez, C. F.; Hallböök, F.; Persson, H.; Cain, L. D.; Dreyfus, C. F.; Black, I. B.

In: Experimental Neurology, Vol. 119, No. 1, 01.1993, p. 72-78.

Research output: Contribution to journalArticle

Friedman, WJ, Ibáñez, CF, Hallböök, F, Persson, H, Cain, LD, Dreyfus, CF & Black, IB 1993, 'Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain', Experimental Neurology, vol. 119, no. 1, pp. 72-78. https://doi.org/10.1006/exnr.1993.1007
Friedman WJ, Ibáñez CF, Hallböök F, Persson H, Cain LD, Dreyfus CF et al. Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain. Experimental Neurology. 1993 Jan;119(1):72-78. https://doi.org/10.1006/exnr.1993.1007
Friedman, W. J. ; Ibáñez, C. F. ; Hallböök, F. ; Persson, H. ; Cain, L. D. ; Dreyfus, C. F. ; Black, I. B. / Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain. In: Experimental Neurology. 1993 ; Vol. 119, No. 1. pp. 72-78.
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