Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-β Fibril Seed

Keyphrases

• Amyloid Fibrils 100%
• Senile Plaques 100%
• Neurofibrillary Tangles 100%
• Differential Binding 100%
• Conformational Dynamics 100%
• Lateral Surface 100%
• Binding Dynamics 100%
• Microtubule-binding Repeats 100%
• Hydrogen Donor 66%
• Cross-interaction 66%
• Hydrogen Bonds (H-bonds) 33%
• Molecular Mechanism 33%
• Alzheimer's Disease 33%
• Cognitive Function 33%
• Alzheimer's Disease Pathology 33%
• Distinct Roles 33%
• Fibrillization 33%
• Free Energy Barrier 33%
• Binding Preference 33%
• Sheet Forming 33%
• Local Concentration 33%
• Tau Aggregation 33%
• Cross-seeding 33%
• Binding Structure 33%
• Discrete Molecular Dynamics 33%
• Fibril Elongation 33%
• Interaction Hotspot 33%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• Tau 100%
• Amyloid Protein 100%
• Neurofibrillary Tangle 30%
• Senile Plaque 30%
• Hydrogen Bond 20%