Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder; Marinella Roberti; Alan P. Kozikowski; Kenneth M. Johnson; John S. Bergmann

doi:10.1016/S0960-894X(01)80133-5

Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder, Marinella Roberti, Alan P. Kozikowski, Kenneth M. Johnson, John S. Bergmann

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

Original language	English (US)
Pages (from-to)	303-308
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(01)80133-5
State	Published - Jan 20 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80133-5

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title = "Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen",

abstract = "Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.",

author = "Johannes Stoelwinder and Marinella Roberti and Kozikowski, {Alan P.} and Johnson, {Kenneth M.} and Bergmann, {John S.}",

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AU - Roberti, Marinella

AU - Kozikowski, Alan P.

AU - Johnson, Kenneth M.

AU - Bergmann, John S.

PY - 1994/1/20

Y1 - 1994/1/20

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AB - Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

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Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Abstract

ASJC Scopus subject areas

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