Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder, Marinella Roberti, Alan P. Kozikowski, Kenneth M. Johnson, John S. Bergmann

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number2
DOIs
StatePublished - Jan 20 1994

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Cocaine
Dopamine
Nitrogen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen. / Stoelwinder, Johannes; Roberti, Marinella; Kozikowski, Alan P.; Johnson, Kenneth M.; Bergmann, John S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 2, 20.01.1994, p. 303-308.

Research output: Contribution to journalArticle

Stoelwinder, Johannes ; Roberti, Marinella ; Kozikowski, Alan P. ; Johnson, Kenneth M. ; Bergmann, John S. / Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 2. pp. 303-308.
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