Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder; Marinella Roberti; Alan P. Kozikowski; Kenneth M. Johnson; John S. Bergmann

doi:10.1016/S0960-894X(01)80133-5

Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder
, Marinella Roberti
, Alan P. Kozikowski
, Kenneth M. Johnson
, John S. Bergmann

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

Original language	English (US)
Pages (from-to)	303-308
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(01)80133-5
State	Published - Jan 20 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(01)80133-5

Cite this

@article{03d07ad0031d4e338464246d109b7d51,

title = "Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen",

abstract = "Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.",

author = "Johannes Stoelwinder and Marinella Roberti and Kozikowski, \{Alan P.\} and Johnson, \{Kenneth M.\} and Bergmann, \{John S.\}",

year = "1994",

month = jan,

day = "20",

doi = "10.1016/S0960-894X(01)80133-5",

language = "English (US)",

volume = "4",

pages = "303--308",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

AU - Stoelwinder, Johannes

AU - Roberti, Marinella

AU - Kozikowski, Alan P.

AU - Johnson, Kenneth M.

AU - Bergmann, John S.

PY - 1994/1/20

Y1 - 1994/1/20

N2 - Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

AB - Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

UR - https://www.scopus.com/pages/publications/0028280616

UR - https://www.scopus.com/pages/publications/0028280616#tab=citedBy

U2 - 10.1016/S0960-894X(01)80133-5

DO - 10.1016/S0960-894X(01)80133-5

M3 - Article

AN - SCOPUS:0028280616

SN - 0960-894X

VL - 4

SP - 303

EP - 308

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this