Differential c-jun gene expression with tonically administered steroids in rat ovary and uterus

M. E. Shelley, Amjad Hossain, P. G. McDonough, I. Khan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to evaluate the induction of the early regulatory gene c-jun in response to tonic exposure to estradiol and progesterone in rat ovary, uterus, and adrenal tissues. STUDY DESIGN: Pellets containing estradiol-17β, progesterone, and estradiol-17β plus progesterone were placed subcutaneously in immature female Sprague-Dawley rats (N = 24). The ovary, uterus, and the adrenal were evaluated for c-jun expression by Northern analysis at 24 and 48 hours. RESULTS: The c-jun messenger ribonucleic acid expression in the ovary and adrenal gland was inhibited with high, nonphysiologic doses of estradiol in progesterone and was induced with physiologic levels of estradiol. Physiologic levels of progesterone do not appear to influence the expression of c-jun in the ovary or adrenal gland. Uterine c-jun expression to estradiol and progesterone is generally the opposite of that observed in the ovary. CONCLUSION: These findings suggest that there is both tissue and dose specificity of c-jun gene expression in steroidogenic and steroid-responsive tissues when steroid hormones are tonically administered.

Original languageEnglish (US)
Pages (from-to)1410-1415
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume170
Issue number5 I
StatePublished - 1994
Externally publishedYes

Fingerprint

jun Genes
Uterus
Progesterone
Ovary
Estradiol
Steroids
Gene Expression
Adrenal Glands
Organ Specificity
Regulator Genes
Sprague Dawley Rats
Hormones
RNA

Keywords

  • c-jun
  • estradiol
  • progesterone
  • Protooncogene

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Differential c-jun gene expression with tonically administered steroids in rat ovary and uterus. / Shelley, M. E.; Hossain, Amjad; McDonough, P. G.; Khan, I.

In: American Journal of Obstetrics and Gynecology, Vol. 170, No. 5 I, 1994, p. 1410-1415.

Research output: Contribution to journalArticle

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