Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

Li Li; Alan Barrett; David Beasley

doi:10.1016/j.virol.2005.02.011

Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

Li Li, Alan Barrett, David Beasley

Research output: Contribution to journal › Article

49 Scopus citations

Abstract

Neutralization of flaviviruses by antibody is primarily mediated via epitopes in the viral envelope (E) protein. Comparative studies using neutralizing monoclonal antibodies revealed differential expression of epitopes within the E protein domain III of ten naturally occurring West Nile virus strains representing major subtypes of genetic lineages 1 and 2. Residues that defined these subtype-specific determinants were identified by mutational studies and found to be surface exposed in the domain III structure. Mutations of residue 332 had the most significant effects on variation of domain III neutralizing epitopes among strains.

Original language	English (US)
Pages (from-to)	99-105
Number of pages	7
Journal	Virology
Volume	335
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2005.02.011
State	Published - Apr 25 2005

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Keywords

Envelope protein
Flavivirus
Neutralizing epitope
West Nile virus

ASJC Scopus subject areas

Virology
Infectious Diseases

Cite this

Li, L., Barrett, A., & Beasley, D. (2005). Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains. Virology, 335(1), 99-105. https://doi.org/10.1016/j.virol.2005.02.011

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Access to Document

10.1016/j.virol.2005.02.011