Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

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Abstract

Neutralization of flaviviruses by antibody is primarily mediated via epitopes in the viral envelope (E) protein. Comparative studies using neutralizing monoclonal antibodies revealed differential expression of epitopes within the E protein domain III of ten naturally occurring West Nile virus strains representing major subtypes of genetic lineages 1 and 2. Residues that defined these subtype-specific determinants were identified by mutational studies and found to be surface exposed in the domain III structure. Mutations of residue 332 had the most significant effects on variation of domain III neutralizing epitopes among strains.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalVirology
Volume335
Issue number1
DOIs
StatePublished - Apr 25 2005

Keywords

  • Envelope protein
  • Flavivirus
  • Neutralizing epitope
  • West Nile virus

ASJC Scopus subject areas

  • Virology

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