Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn

James E. Mace, Myung S. Park, Alejandra G. Mora, Kevin K. Chung, Wenjun Martini, Christopher E. White, John B. Holcomb, Gerald A. Merrill, Michael A. Dubick, Steven Wolf, Charles E. Wade, Martin G. Schwacha

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rationale: Cytokines are central mediators of the immune-inflammatory response to injury and subsequent multiple organ dysfunction syndrome (MODS). Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically. Methods: A prospective database of trauma patients admitted between May 2004 and September 2007 to the burn or surgical intensive care units within 24 h of injury with an anticipated stay of at least 72 h was analyzed. Sequential clinical and laboratory parameters were collected in the first week, including multiplex analysis data for plasma levels of inflammatory cytokines (IL-6, and IL-8). Patients with known pre-injury coagulopathy were excluded. A Marshall score of 10 or greater was defined as MODS. Results: A total of 179 patients were enrolled (67 burn and 112 non-burn). Plasma IL-6 and IL-8 levels were markedly elevated in both burn and non-burn patients compared to healthy volunteers. Burn subjects had higher levels of IL-6 and IL-8 than the non-burn on days 1 through 7 after injury. Subjects with burns and at least 30% total body surface area were older and had a lower injury severity score, a higher prevalence of MODS, and correspondingly higher mortality. Multivariate analysis of injury type, MODS, and time did not demonstrate an influence of MODS. Conclusions: Burns were associated with a greater and more sustained immune-inflammatory response than non-burn trauma as evidenced by elevated plasma IL-6 and IL-8 levels during the first week. There was no association between MODS and plasma cytokine levels.

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
JournalBurns
Volume38
Issue number4
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Multiple Organ Failure
Wounds and Injuries
Interleukin-8
Interleukin-6
Cytokines
Burns
Injury Severity Score
Body Surface Area
Critical Care
Intensive Care Units
Healthy Volunteers
Multivariate Analysis
Databases
Mortality

Keywords

  • Burn
  • Cytokine
  • Inflammation
  • Interleukin-6
  • Interleukin-8
  • Multiple
  • Trauma

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Mace, J. E., Park, M. S., Mora, A. G., Chung, K. K., Martini, W., White, C. E., ... Schwacha, M. G. (2012). Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn. Burns, 38(4), 599-606. https://doi.org/10.1016/j.burns.2011.10.013

Differential expression of the immunoinflammatory response in trauma patients : Burn vs. non-burn. / Mace, James E.; Park, Myung S.; Mora, Alejandra G.; Chung, Kevin K.; Martini, Wenjun; White, Christopher E.; Holcomb, John B.; Merrill, Gerald A.; Dubick, Michael A.; Wolf, Steven; Wade, Charles E.; Schwacha, Martin G.

In: Burns, Vol. 38, No. 4, 01.06.2012, p. 599-606.

Research output: Contribution to journalArticle

Mace, JE, Park, MS, Mora, AG, Chung, KK, Martini, W, White, CE, Holcomb, JB, Merrill, GA, Dubick, MA, Wolf, S, Wade, CE & Schwacha, MG 2012, 'Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn', Burns, vol. 38, no. 4, pp. 599-606. https://doi.org/10.1016/j.burns.2011.10.013
Mace, James E. ; Park, Myung S. ; Mora, Alejandra G. ; Chung, Kevin K. ; Martini, Wenjun ; White, Christopher E. ; Holcomb, John B. ; Merrill, Gerald A. ; Dubick, Michael A. ; Wolf, Steven ; Wade, Charles E. ; Schwacha, Martin G. / Differential expression of the immunoinflammatory response in trauma patients : Burn vs. non-burn. In: Burns. 2012 ; Vol. 38, No. 4. pp. 599-606.
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AU - Mace, James E.

AU - Park, Myung S.

AU - Mora, Alejandra G.

AU - Chung, Kevin K.

AU - Martini, Wenjun

AU - White, Christopher E.

AU - Holcomb, John B.

AU - Merrill, Gerald A.

AU - Dubick, Michael A.

AU - Wolf, Steven

AU - Wade, Charles E.

AU - Schwacha, Martin G.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Rationale: Cytokines are central mediators of the immune-inflammatory response to injury and subsequent multiple organ dysfunction syndrome (MODS). Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically. Methods: A prospective database of trauma patients admitted between May 2004 and September 2007 to the burn or surgical intensive care units within 24 h of injury with an anticipated stay of at least 72 h was analyzed. Sequential clinical and laboratory parameters were collected in the first week, including multiplex analysis data for plasma levels of inflammatory cytokines (IL-6, and IL-8). Patients with known pre-injury coagulopathy were excluded. A Marshall score of 10 or greater was defined as MODS. Results: A total of 179 patients were enrolled (67 burn and 112 non-burn). Plasma IL-6 and IL-8 levels were markedly elevated in both burn and non-burn patients compared to healthy volunteers. Burn subjects had higher levels of IL-6 and IL-8 than the non-burn on days 1 through 7 after injury. Subjects with burns and at least 30% total body surface area were older and had a lower injury severity score, a higher prevalence of MODS, and correspondingly higher mortality. Multivariate analysis of injury type, MODS, and time did not demonstrate an influence of MODS. Conclusions: Burns were associated with a greater and more sustained immune-inflammatory response than non-burn trauma as evidenced by elevated plasma IL-6 and IL-8 levels during the first week. There was no association between MODS and plasma cytokine levels.

AB - Rationale: Cytokines are central mediators of the immune-inflammatory response to injury and subsequent multiple organ dysfunction syndrome (MODS). Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically. Methods: A prospective database of trauma patients admitted between May 2004 and September 2007 to the burn or surgical intensive care units within 24 h of injury with an anticipated stay of at least 72 h was analyzed. Sequential clinical and laboratory parameters were collected in the first week, including multiplex analysis data for plasma levels of inflammatory cytokines (IL-6, and IL-8). Patients with known pre-injury coagulopathy were excluded. A Marshall score of 10 or greater was defined as MODS. Results: A total of 179 patients were enrolled (67 burn and 112 non-burn). Plasma IL-6 and IL-8 levels were markedly elevated in both burn and non-burn patients compared to healthy volunteers. Burn subjects had higher levels of IL-6 and IL-8 than the non-burn on days 1 through 7 after injury. Subjects with burns and at least 30% total body surface area were older and had a lower injury severity score, a higher prevalence of MODS, and correspondingly higher mortality. Multivariate analysis of injury type, MODS, and time did not demonstrate an influence of MODS. Conclusions: Burns were associated with a greater and more sustained immune-inflammatory response than non-burn trauma as evidenced by elevated plasma IL-6 and IL-8 levels during the first week. There was no association between MODS and plasma cytokine levels.

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