Differential modulation of murine host immune response by salivary gland extracts from the mosquitoes Aedes aegypti and Culex quinquefasciatus

N. Wanasen, R. H. Nussenzveig, D. E. Champagne, Lynn Soong, S. Higgs

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Mosquitoes (Diptera: Culicidae) are major vectors of numerous infectious agents. Compounds in mosquito saliva not only facilitate blood-feeding, but may also have an impact upon the immune system of vertebrate hosts. Consequently, the exposure to mosquito saliva may influence pathogen transmission, establishment and disease development. Using two medically important vector mosquitoes, Aedes aegypti (L.) and Culex quinquefasciatus Say, we examined the effects of mosquito saliva on immune cells of host mice. After antigen-specific or non-specific stimulation, murine splenocyte proliferation and production of both Th1 and Th2 cytokines were significantly reduced in the presence of salivary gland extract (SGE) from Ae. aegypti, but not SGE from Cx. quinquefasciatus. T cell populations were highly susceptible to this suppression, showing increased mortality and reduced division rates - judged by flow cytometric analyses. Evidently these two culicine mosquitoes differ in their host immunomodulatory activities.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalMedical and Veterinary Entomology
Volume18
Issue number2
DOIs
StatePublished - Jun 2004

Fingerprint

Culex
Culex quinquefasciatus
Aedes
salivary glands
Aedes aegypti
Salivary Glands
immune response
Culicidae
mosquito
saliva
mice
extracts
Saliva
hemophagy
Infectious Disease Transmission
immune system
antigen
pathogens
Diptera
splenocytes

Keywords

  • Aedes aegypti
  • Culex quinquefasciatus
  • Cytokines
  • Immunomodulation
  • Mosquito saliva
  • Mouse
  • Splenocytes
  • T cell populations
  • Th cytokines
  • Vector-host-pathogen relationships
  • Vertebrate immune response

ASJC Scopus subject areas

  • Insect Science
  • veterinary(all)

Cite this

Differential modulation of murine host immune response by salivary gland extracts from the mosquitoes Aedes aegypti and Culex quinquefasciatus. / Wanasen, N.; Nussenzveig, R. H.; Champagne, D. E.; Soong, Lynn; Higgs, S.

In: Medical and Veterinary Entomology, Vol. 18, No. 2, 06.2004, p. 191-199.

Research output: Contribution to journalArticle

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