Differential requirement for CD18 in T-helper effector homing

Seung Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Felix Shardonofsky, Huifang Lu, Arthur L. Beaudet, C. Wayne Smith, Lynn Soong, David B. Corry

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33 Scopus citations

Abstract

To understand the integrin requirements of T-helper (TH) effector subsets, we investigated the contribution of CD18 (β2 integrin) to TH1 and TH2 function in vitro and in relevant disease models. CD18-deficient (Itgb2-/-) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2 -/- mice were better able to resolve Leishmania major infection and generated a superior TH1 immune response, as assessed from draining lymph nodes. In contrast, TH2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of TH1 and TH2 cells in spleens was normal, but accumulation of T H2 (not TH1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for TH2, but not TH1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T H2 cells.

Original languageEnglish (US)
Pages (from-to)1281-1286
Number of pages6
JournalNature Medicine
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2003

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lee, S. H., Prince, J. E., Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., Beaudet, A. L., Smith, C. W., Soong, L., & Corry, D. B. (2003). Differential requirement for CD18 in T-helper effector homing. Nature Medicine, 9(10), 1281-1286. https://doi.org/10.1038/nm932