Differential requirement for CD18 in T-helper effector homing

Seung Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Felix Shardonofsky, Huifang Lu, Arthur L. Beaudet, C. Wayne Smith, Lynn Soong, David B. Corry

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To understand the integrin requirements of T-helper (TH) effector subsets, we investigated the contribution of CD18 (β2 integrin) to TH1 and TH2 function in vitro and in relevant disease models. CD18-deficient (Itgb2-/-) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2 -/- mice were better able to resolve Leishmania major infection and generated a superior TH1 immune response, as assessed from draining lymph nodes. In contrast, TH2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of TH1 and TH2 cells in spleens was normal, but accumulation of T H2 (not TH1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for TH2, but not TH1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T H2 cells.

Original languageEnglish (US)
Pages (from-to)1281-1286
Number of pages6
JournalNature Medicine
Volume9
Issue number10
DOIs
StatePublished - Oct 2003

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Integrins
Leishmania major
Pulmonary diseases
T-cells
Lung Diseases
Spleen
Lymph Nodes
T-Lymphocytes
Infection
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lee, S. H., Prince, J. E., Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., ... Corry, D. B. (2003). Differential requirement for CD18 in T-helper effector homing. Nature Medicine, 9(10), 1281-1286. https://doi.org/10.1038/nm932

Differential requirement for CD18 in T-helper effector homing. / Lee, Seung Hyo; Prince, Joseph E.; Rais, Muhammad; Kheradmand, Farrah; Shardonofsky, Felix; Lu, Huifang; Beaudet, Arthur L.; Smith, C. Wayne; Soong, Lynn; Corry, David B.

In: Nature Medicine, Vol. 9, No. 10, 10.2003, p. 1281-1286.

Research output: Contribution to journalArticle

Lee, SH, Prince, JE, Rais, M, Kheradmand, F, Shardonofsky, F, Lu, H, Beaudet, AL, Smith, CW, Soong, L & Corry, DB 2003, 'Differential requirement for CD18 in T-helper effector homing', Nature Medicine, vol. 9, no. 10, pp. 1281-1286. https://doi.org/10.1038/nm932
Lee SH, Prince JE, Rais M, Kheradmand F, Shardonofsky F, Lu H et al. Differential requirement for CD18 in T-helper effector homing. Nature Medicine. 2003 Oct;9(10):1281-1286. https://doi.org/10.1038/nm932
Lee, Seung Hyo ; Prince, Joseph E. ; Rais, Muhammad ; Kheradmand, Farrah ; Shardonofsky, Felix ; Lu, Huifang ; Beaudet, Arthur L. ; Smith, C. Wayne ; Soong, Lynn ; Corry, David B. / Differential requirement for CD18 in T-helper effector homing. In: Nature Medicine. 2003 ; Vol. 9, No. 10. pp. 1281-1286.
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