Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections

Gavin C. Bowick, Susan M. Fennewald, Barry L. Elsom, Judith Aronson, Bruce A. Luxon, David G. Gorenstein, Norbert K. Herzog

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25 Scopus citations

Abstract

The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determinants which lead to either viral clearance or lethal disease. By analyzing protein level changes using pathway analysis, we have identified key intermediates which may be targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)10248-10252
Number of pages5
JournalJournal of Virology
Volume80
Issue number20
DOIs
StatePublished - Oct 2006

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ASJC Scopus subject areas

  • Immunology

Cite this

Bowick, G. C., Fennewald, S. M., Elsom, B. L., Aronson, J., Luxon, B. A., Gorenstein, D. G., & Herzog, N. K. (2006). Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections. Journal of Virology, 80(20), 10248-10252. https://doi.org/10.1128/JVI.01384-06