Differential vascular actions of ethanol in feline middle cerebral and mesenteric artery.

M. Faragó, Csaba Szabo, I. Horváth, E. Dóra, A. G. Kovách

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The vascular actions of ethanol on feline middle cerebral and mesenteric arteries were investigated in vitro. Ethanol (20-500 mM) caused potent contraction in cerebral arteries, but it contracted the mesenteric arteries only weakly. In the middle cerebral artery (but not in the mesenteric artery) ethanol (300 mM) potentiated the noradrenaline (5.10(-6) M) induced contractions. Antiserum for endothelin (in an appropriate concentration to inhibit endothelin-induced contraction; 0.02 mg/ml) did not inhibit the ethanol-induced contractions. Endothelium-dependent relaxations induced by acetylcholine and ATP were also affected by ethanol (300 mM); in the cerebral artery acetylcholine- but not ATP-induced relaxations, whereas in the mesenteric artery ATP- but not acetylcholine-induced relaxations were inhibited significantly. The results suggest that ethanol causes strong (endothelin-independent) contraction and facilitates the response to noradrenaline in the middle cerebral, but not in the mesenteric artery; and it selectively inhibits endothelium-dependent relaxation. These actions of ethanol may contribute to the development of vascular diseases.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalActa Physiologica Hungarica
Volume78
Issue number2
StatePublished - 1991
Externally publishedYes

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Mesenteric Arteries
Felidae
Middle Cerebral Artery
Blood Vessels
Ethanol
Endothelins
Acetylcholine
Cerebral Arteries
Adenosine Triphosphate
Endothelium
Norepinephrine
Vascular Diseases
Immune Sera

ASJC Scopus subject areas

  • Physiology

Cite this

Differential vascular actions of ethanol in feline middle cerebral and mesenteric artery. / Faragó, M.; Szabo, Csaba; Horváth, I.; Dóra, E.; Kovách, A. G.

In: Acta Physiologica Hungarica, Vol. 78, No. 2, 1991, p. 119-125.

Research output: Contribution to journalArticle

Faragó, M, Szabo, C, Horváth, I, Dóra, E & Kovách, AG 1991, 'Differential vascular actions of ethanol in feline middle cerebral and mesenteric artery.', Acta Physiologica Hungarica, vol. 78, no. 2, pp. 119-125.
Faragó, M. ; Szabo, Csaba ; Horváth, I. ; Dóra, E. ; Kovách, A. G. / Differential vascular actions of ethanol in feline middle cerebral and mesenteric artery. In: Acta Physiologica Hungarica. 1991 ; Vol. 78, No. 2. pp. 119-125.
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