Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

Kathryn Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalEuropean Journal of Pharmacology
Volume108
Issue number2
DOIs
StatePublished - Jan 22 1985
Externally publishedYes

Fingerprint

5-Hydroxytryptophan
Lysergic Acid Diethylamide
Ketanserin
Serotonin Antagonists
Serotonin
Benserazide
Hallucinogens
Carboxy-Lyases
Pharmaceutical Preparations
Cues
Water

Keywords

  • 1-5-Hydroxytryptophan
  • d-Lysergic acid diethylamide (LSD)
  • Drug discrimination
  • Serotonin (5-hydroxytryptamine)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD. / Cunningham, Kathryn; Callahan, Patrick M.; Appel, James B.

In: European Journal of Pharmacology, Vol. 108, No. 2, 22.01.1985, p. 179-186.

Research output: Contribution to journalArticle

Cunningham, Kathryn ; Callahan, Patrick M. ; Appel, James B. / Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD. In: European Journal of Pharmacology. 1985 ; Vol. 108, No. 2. pp. 179-186.
@article{1674b346c9144270829c93f2b2e5b780,
title = "Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD",
abstract = "The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50{\%} drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).",
keywords = "1-5-Hydroxytryptophan, d-Lysergic acid diethylamide (LSD), Drug discrimination, Serotonin (5-hydroxytryptamine)",
author = "Kathryn Cunningham and Callahan, {Patrick M.} and Appel, {James B.}",
year = "1985",
month = "1",
day = "22",
doi = "10.1016/0014-2999(85)90723-X",
language = "English (US)",
volume = "108",
pages = "179--186",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

AU - Cunningham, Kathryn

AU - Callahan, Patrick M.

AU - Appel, James B.

PY - 1985/1/22

Y1 - 1985/1/22

N2 - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

AB - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

KW - 1-5-Hydroxytryptophan

KW - d-Lysergic acid diethylamide (LSD)

KW - Drug discrimination

KW - Serotonin (5-hydroxytryptamine)

UR - http://www.scopus.com/inward/record.url?scp=0021964089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021964089&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(85)90723-X

DO - 10.1016/0014-2999(85)90723-X

M3 - Article

C2 - 3156756

AN - SCOPUS:0021964089

VL - 108

SP - 179

EP - 186

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -