Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

Kathryn A. Cunningham; Patrick M. Callahan; James B. Appel

doi:10.1016/0014-2999(85)90723-X

Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

Kathryn A. Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

Original language	English (US)
Pages (from-to)	179-186
Number of pages	8
Journal	European Journal of Pharmacology
Volume	108
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(85)90723-X
State	Published - Jan 22 1985
Externally published	Yes

Keywords

1-5-Hydroxytryptophan
Drug discrimination
Serotonin (5-hydroxytryptamine)
d-Lysergic acid diethylamide (LSD)

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(85)90723-X

Cite this

@article{1674b346c9144270829c93f2b2e5b780,

title = "Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD",

abstract = "The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).",

keywords = "1-5-Hydroxytryptophan, Drug discrimination, Serotonin (5-hydroxytryptamine), d-Lysergic acid diethylamide (LSD)",

author = "Cunningham, {Kathryn A.} and Callahan, {Patrick M.} and Appel, {James B.}",

year = "1985",

month = jan,

day = "22",

doi = "10.1016/0014-2999(85)90723-X",

language = "English (US)",

volume = "108",

pages = "179--186",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

AU - Cunningham, Kathryn A.

AU - Callahan, Patrick M.

AU - Appel, James B.

PY - 1985/1/22

Y1 - 1985/1/22

N2 - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

AB - The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

KW - 1-5-Hydroxytryptophan

KW - Drug discrimination

KW - Serotonin (5-hydroxytryptamine)

KW - d-Lysergic acid diethylamide (LSD)

UR - http://www.scopus.com/inward/record.url?scp=0021964089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021964089&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(85)90723-X

DO - 10.1016/0014-2999(85)90723-X

M3 - Article

C2 - 3156756

AN - SCOPUS:0021964089

SN - 0014-2999

VL - 108

SP - 179

EP - 186

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this