Differentiation of a human monocytic cell line associated with increased production of Rift Valley fever virus by infected cells

Richard M. Lewis, Thomas M. Cosgriff, Clarence J. Peters, John C. Morrill

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Rift Valley fever (RVF) virus is a cause of significant human and animal disease in many parts of Africa. In some cases, it causes a hemorrhagic fever, which is frequently fatal. Prior studies have shown that RVF virus productively infects peritoneal macrophages from susceptible rat strains. The U937 human monocytic cell line was used to determine the effect of monocytic cell differentiation on the degree of viral production by cell cultures infected with RVF virus. Differentiation of U937 cells to more mature monocytic cells by phorbol ester resulted in production of 10 times more infectious virions in comparison with undifferentiated cells. These studies imply that monocytic cell differentiation increases permissiveness for RVF virus production.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalJournal of Medical Virology
Volume23
Issue number3
DOIs
StatePublished - Nov 1987

Keywords

  • macrophage
  • monocyte
  • phorbol ester

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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