Diffuse Chorangiomatosis as a Cause of Cardiomegaly, Microangiopathic Hemolytic Anemia and Thrombocytopenia in a Newborn

Shreyas Arya, Vidit Bhargava, Carol Richardson, Hal K. Hawkins

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: The hallmark of diffuse chorangiomatosis is capillary dysvasculogenesis, diffusely involving the placenta. It can cause massive placental enlargement and may have adverse fetal effects. Case report: A 32 weeks gestation male infant was born via cesarean section and had a placenta weighing 900 g. There was diffuse vascular proliferation involving the stem villi and intermediate villi. Short Nucleotide Polymorphism (SNP) microarray analysis of the placenta showed no biparental mosaicism or loss of heterozygosity, ruling out placental mesenchymal dysplasia. The infant also had cardiomegaly, microangiopathic hemolytic anemia and thrombocytopenia which spontaneously improved over time. Conclusion: Diffuse chorangiomatosis can be associated with hemolysis, thrombocytopenia and cardiomegaly in the newborn. However, once delivered, these findings can spontaneously resolve over time.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
JournalFetal and Pediatric Pathology
Volume36
Issue number6
DOIs
StatePublished - Nov 2 2017

Keywords

  • cardiomegaly
  • Diffuse or multifocal chorangiomatosis
  • microangiopathic hemolytic anemia
  • placental villous capillary lesions
  • thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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