Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia

Yimin Ge, Mahmoud A. Eltorky, Randy D. Ernst, Claudia Y. Castro

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia is an extremely rare pulmonary lesion, with only 39 cases reported in the literature. We report an additional case and review the literature. The patient is a 41-year-old man with a 5-year history of progressive dyspnea, cough, and wheezing. He was initially diagnosed as having bronchial asthma but did not respond to treatment of bronchodilators and inhaled steroids. Pulmonary function tests showed airflow obstruction. Chest computed tomography revealed a mosaic pattern of air trapping and thickening of bronchial walls. Open lung biopsy showed diffuse proliferation of pulmonary neuroendocrine cells within the bronchiolar epithelium, often bulging into or obliterating the bronchiolar lumen. These cells also breached the basement membrane, forming tumorlets. There was prominent peribronchiolar fibrosis and obliterative bronchiolitis. The pathologic evaluation of lung tissue is currently the gold standard in making a definitive diagnosis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, and all the reported cases were diagnosed by either open lung biopsy or lobectomy.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume11
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Neuroendocrine Cells
Hyperplasia
Lung
Biopsy
Bronchiolitis
Bronchodilator Agents
Respiratory Function Tests
Respiratory Sounds
Cough
Basement Membrane
Dyspnea
Fibrosis
Thorax
Asthma
Epithelium
Steroids
Air
Tomography

Keywords

  • Immunohistochemistry
  • Lung
  • Neuroendocrine hyperplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. / Ge, Yimin; Eltorky, Mahmoud A.; Ernst, Randy D.; Castro, Claudia Y.

In: Annals of Diagnostic Pathology, Vol. 11, No. 2, 04.2007, p. 122-126.

Research output: Contribution to journalArticle

Ge, Yimin ; Eltorky, Mahmoud A. ; Ernst, Randy D. ; Castro, Claudia Y. / Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. In: Annals of Diagnostic Pathology. 2007 ; Vol. 11, No. 2. pp. 122-126.
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